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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptentm1.1Mwst
targeted mutation 1.1, Michael Weinstein
MGI:4366755
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(TPO-cre)1Shk/0 		involves: 129 * FVB/NCr MGI:5897778
cn2
 		Prkar1atm1.2Lsk/Prkar1atm1.2Lsk
Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(TPO-cre)1Shk/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/NCr MGI:5897675
cn3
 		Prkar1atm1.2Lsk/Prkar1a+
Ptentm1.1Mwst/Pten+
Tg(TPO-cre)1Shk/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/NCr MGI:5897775
cn4
 		Ets2tm1Rgo/Ets2tm5.1Rgo
Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(S100a4-cre)1Gle/0 		involves: 129S2/SvPas * FVB/N MGI:4366764
cn5
 		Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(MMTVneu)202Mul/0
Tg(S100a4-cre)1Gle/0 		involves: FVB/N MGI:4366766
cn6
 		Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(S100a4-cre)1Gle/0 		involves: FVB/N MGI:4366765


Genotype
MGI:5897778
cn1
Allelic
Composition		 Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(TPO-cre)1Shk/0
Genetic
Background		 involves: 129 * FVB/NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1.1Mwst mutation (0 available); any Pten mutation (88 available)
Tg(TPO-cre)1Shk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal thyroid follicular cell morphology ( J:225245 )
• mice exhibit benign follicular thyroid hyperplasia




Genotype
MGI:5897675
cn2
Allelic
Composition		 Prkar1atm1.2Lsk/Prkar1atm1.2Lsk
Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(TPO-cre)1Shk/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar1atm1.2Lsk mutation (1 available); any Prkar1a mutation (19 available)
Ptentm1.1Mwst mutation (0 available); any Pten mutation (88 available)
Tg(TPO-cre)1Shk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:225245 )
• median survival age of 6 months

growth/size/body
weight loss ( J:225245 )
• males exhibit lower body weight beginning at 1 month of age which becomes statistically significant at 5 months of age

endocrine/exocrine glands
increased thyroid carcinoma incidence ( J:225245 )
• 100% of mice develop follicular thyroid carcinoma by 8 weeks of age, showing capsular and/or vascular invasion
• tumors show a molecular signature similar to human sporadic follicular thyroid cancer
increased activity of thyroid gland ( J:225245 )
• mice are hyperthyroid

adipose tissue
decreased subcutaneous adipose tissue amount ( J:225245 )
• reduction in subcutaneous adipose tissue
decreased abdominal adipose tissue amount ( J:225245 )
• reduction in visceral adipose tissue

homeostasis/metabolism
increased circulating thyroxine level ( J:225245 )
• free T4 levels are increased

integument
decreased subcutaneous adipose tissue amount ( J:225245 )
• reduction in subcutaneous adipose tissue

neoplasm
increased thyroid carcinoma incidence ( J:225245 )
• 100% of mice develop follicular thyroid carcinoma by 8 weeks of age, showing capsular and/or vascular invasion
• tumors show a molecular signature similar to human sporadic follicular thyroid cancer
increased metastatic potential ( J:225245 )
• metastatic follicular thyroid carcinoma is seen in the lungs of 27% of mice; metastases are well differentiated, maintain follicular structure with colloid, and stain for thyroglobulin
• tumors exhibit only mild increases in proliferation rate compared to those in single homozygous Prkar1atm1.2Lsk Tg(TPO-cre)1Shk/0 mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
follicular thyroid carcinoma DOID:3962 OMIM:188470
 J:241066




Genotype
MGI:5897775
cn3
Allelic
Composition		 Prkar1atm1.2Lsk/Prkar1a+
Ptentm1.1Mwst/Pten+
Tg(TPO-cre)1Shk/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar1atm1.2Lsk mutation (1 available); any Prkar1a mutation (19 available)
Ptentm1.1Mwst mutation (0 available); any Pten mutation (88 available)
Tg(TPO-cre)1Shk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:225245 )
• mice exhibit reduced survival compared to single heterozygotes

neoplasm
neoplasm ( J:225245 )
N
• mice do not show increased incidence of thyroid cancer




Genotype
MGI:4366764
cn4
Allelic
Composition		 Ets2tm1Rgo/Ets2tm5.1Rgo
Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(S100a4-cre)1Gle/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm1Rgo mutation (1 available); any Ets2 mutation (39 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (39 available)
Ptentm1.1Mwst mutation (0 available); any Pten mutation (88 available)
Tg(S100a4-cre)1Gle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased mammary gland tumor incidence ( J:153747 )
• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(S100a4-cre)1Gle mice
increased mammary gland tumor incidence ( J:153747 )
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes
abnormal tumor morphology ( J:153747 )
• mammary tumors induced by NT2.5 exhibit decreased numbers of macrophages and recruitment of new vasculature compared to in similarly treated Ptentm1.1Mwst homozygotes

integument
decreased mammary gland tumor incidence ( J:153747 )
• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(S100a4-cre)1Gle mice
increased mammary gland tumor incidence ( J:153747 )
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes

endocrine/exocrine glands
decreased mammary gland tumor incidence ( J:153747 )
• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(S100a4-cre)1Gle mice
increased mammary gland tumor incidence ( J:153747 )
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes




Genotype
MGI:4366766
cn5
Allelic
Composition		 Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(MMTVneu)202Mul/0
Tg(S100a4-cre)1Gle/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1.1Mwst mutation (0 available); any Pten mutation (88 available)
Tg(MMTVneu)202Mul mutation (2 available)
Tg(S100a4-cre)1Gle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:153747 )
• mesenchymal cells transplanted into wild-type mice induce more mammary tumors that similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(MMTVneu)202Mul cells
• mammary tumors progress to adenoma, carcinoma in situ, and invasive carcinoma

integument
increased mammary gland tumor incidence ( J:153747 )
• mesenchymal cells transplanted into wild-type mice induce more mammary tumors that similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(MMTVneu)202Mul cells
• mammary tumors progress to adenoma, carcinoma in situ, and invasive carcinoma

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:153747 )
• mesenchymal cells transplanted into wild-type mice induce more mammary tumors that similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(MMTVneu)202Mul cells
• mammary tumors progress to adenoma, carcinoma in situ, and invasive carcinoma




Genotype
MGI:4366765
cn6
Allelic
Composition		 Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(S100a4-cre)1Gle/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1.1Mwst mutation (0 available); any Pten mutation (88 available)
Tg(S100a4-cre)1Gle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:153747 )
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes

integument
increased mammary gland tumor incidence ( J:153747 )
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:153747 )
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory