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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl2l11tm3.1Boui
targeted mutation 3.1, Philippe Bouillet
MGI:4366756
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui C57BL/6-Bcl2l11tm3.1Boui MGI:4366830
cx2
 		Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui 		B6.Cg-Bcl2tm1Dlo Bcl2l11tm3.1Boui MGI:4366837
cx3
 		Bcl2l11tm3.1Boui/Bcl2l11+
Tg(IghMyc)22Bri/0 		involves: C57BL/6 * SJL MGI:5433595
cx4
 		Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Tg(IghMyc)22Bri/0 		involves: C57BL/6 * SJL MGI:5433596


Genotype
MGI:4366830
hm1
Allelic
Composition		 Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Genetic
Background		 C57BL/6-Bcl2l11tm3.1Boui
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm3.1Boui mutation (0 available); any Bcl2l11 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased spleen weight ( J:153846 )
• smaller increase in spleen weight (<1.5 fold)
increased leukocyte cell number ( J:153846 )
• smaller increase in white blood cells numbers (<1.5 fold)

immune system
immune system phenotype ( J:153846 )
N
• normal in vitro survival assays with several cytotoxic stimuli on sorted thymocyte and B cell populations
increased spleen weight ( J:153846 )
• smaller increase in spleen weight (<1.5 fold)
increased leukocyte cell number ( J:153846 )
• smaller increase in white blood cells numbers (<1.5 fold)

growth/size/body
increased spleen weight ( J:153846 )
• smaller increase in spleen weight (<1.5 fold)




Genotype
MGI:4366837
cx2
Allelic
Composition		 Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Genetic
Background		 B6.Cg-Bcl2tm1Dlo Bcl2l11tm3.1Boui
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm3.1Boui mutation (0 available); any Bcl2l11 mutation (36 available)
Bcl2tm1Dlo mutation (0 available); any Bcl2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

The Bcl2l11tm3.1Boui mutation ameliorates the degenerative disorders of Bcl2tm1Dlo/Bcl2tm1Dlo mice

mortality/aging
premature death ( J:153846 )
• live up to 300 days due to mild polycystic kidney disease (PKD)

growth/size/body
polycystic kidney ( J:153846 )
• mild signs of polycystic kidney disease (PKD)
• progress slowly
• live up to 300 days
postnatal growth retardation ( J:153846 )
• retarded growth
• most of these animals (n = 24) become healthy adults
increased spleen weight ( J:153846 )
• spleens are heavier than those in homozygous Bcl-2 deficient mice

hematopoietic system
hematopoietic system phenotype ( J:153846 )
N
• normal splenic structure
decreased splenocyte apoptosis ( J:153846 )
• less apoptosis than in homozygous Bcl-2 deficient mice spleen
increased spleen weight ( J:153846 )
• spleens are heavier than those in homozygous Bcl-2 deficient mice
increased leukocyte cell number ( J:153846 )
• more white blood cells numbers than in homozygous Bcl-2 deficient mice

renal/urinary system
polycystic kidney ( J:153846 )
• mild signs of polycystic kidney disease (PKD)
• progress slowly
• live up to 300 days

immune system
immune system phenotype ( J:153846 )
N
• normal splenic structure
decreased splenocyte apoptosis ( J:153846 )
• less apoptosis than in homozygous Bcl-2 deficient mice spleen
increased spleen weight ( J:153846 )
• spleens are heavier than those in homozygous Bcl-2 deficient mice
increased leukocyte cell number ( J:153846 )
• more white blood cells numbers than in homozygous Bcl-2 deficient mice

cellular
decreased splenocyte apoptosis ( J:153846 )
• less apoptosis than in homozygous Bcl-2 deficient mice spleen




Genotype
MGI:5433595
cx3
Allelic
Composition		 Bcl2l11tm3.1Boui/Bcl2l11+
Tg(IghMyc)22Bri/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm3.1Boui mutation (0 available); any Bcl2l11 mutation (36 available)
Tg(IghMyc)22Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:186117 )
• median lifespan is 110 days, which is similar to single Tg(IghMyc)22Bri hemizygotes

neoplasm
increased B cell derived lymphoma incidence ( J:186117 )
• mutants exhibit a mixture of sIg- pre-B lymphoma (~55%) and sIg+ B lymphoma (~45%)




Genotype
MGI:5433596
cx4
Allelic
Composition		 Bcl2l11tm3.1Boui/Bcl2l11tm3.1Boui
Tg(IghMyc)22Bri/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm3.1Boui mutation (0 available); any Bcl2l11 mutation (36 available)
Tg(IghMyc)22Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:186117 )
• median lifespan is 84 days, which is not statistically different from single Tg(IghMyc)22Bri hemizygotes

neoplasm
increased B cell derived lymphoma incidence ( J:186117 )
• mutants exhibit a mix of sIg- pre-B lymphoma (~50%) and sIg+ B lymphoma (~50%)




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory