Phenotypes associated with this allele

• Allele Symbol: Atp7a^Mo-3Btlr
• Allele Name: mottled 3 Bruce Beutler
• Allele ID: MGI:4366761
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp7a^Mo-3Btlr/Atp7a^Mo-3Btlr	C57BL/6J-Atp7a^Mo-3Btlr	MGI:4366762
ht2	Atp7a^Mo-3Btlr/Atp7a^+	C57BL/6J-Atp7a^Mo-3Btlr	MGI:5441737
ot3	Atp7a^Mo-3Btlr/Y	C57BL/6J-Atp7a^Mo-3Btlr	MGI:4366763

Genotype
MGI:4366762

hm1

• Allelic Composition: Atp7a^Mo-3Btlr/Atp7a^Mo-3Btlr
• Genetic Background: C57BL/6J-Atp7a^Mo-3Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Coat color phenotypes of mutants carrying the Atp7a^Mo-Btlr, Atp7a^Mo-2Btlr, or Atp7a^Mo-3Btlr allele

pigmentation

abnormal coat/hair pigmentation ( J:153280 , J:188598 )

♀ • brown coat color with normal pigmentation of the skin and eyes (J:153280)

♀ (J:188598)

integument

abnormal coat/hair pigmentation ( J:153280 , J:188598 )

♀ • brown coat color with normal pigmentation of the skin and eyes (J:153280)

♀ (J:188598)

Genotype
MGI:5441737

ht2

• Allelic Composition: Atp7a^Mo-3Btlr/Atp7a⁺
• Genetic Background: C57BL/6J-Atp7a^Mo-3Btlr

Coat color phenotypes of mutants carrying the Atp7a^Mo-Btlr, Atp7a^Mo-2Btlr, or Atp7a^Mo-3Btlr allele

integument

integument phenotype ( J:188598 )

♀N • unlike other mutations in this gene, heterozygotes do not present with variegated coat color

Genotype
MGI:4366763

ot3

• Allelic Composition: Atp7a^Mo-3Btlr/Y
• Genetic Background: C57BL/6J-Atp7a^Mo-3Btlr

Coat color phenotypes of mutants carrying the Atp7a^Mo-Btlr, Atp7a^Mo-2Btlr, or Atp7a^Mo-3Btlr allele

pigmentation

abnormal coat/hair pigmentation ( J:153280 , J:188598 )

♂ • brown coat color with normal pigmentation of the skin and eyes (J:153280)

♂ (J:188598)

homeostasis/metabolism

decreased brain copper level ( J:188598 )

♂ • decreased by 60% compared to control littermates

immune system

decreased susceptibility to prion infection ( J:188598 )

♂ • following intracranial infection with the Rocky Mountain Laboratory strain of mouse scrapie only 1 of 10 mice became sick within 161 days after infection while all wild-type controls became ill in the same time span

♂ • all mice became terminally ill by 180 days post scrapie infection

♂ • the amount of proteinase-resistant prion protein in the brains of clinically ill mice is reduced compared to controls

nervous system

decreased brain copper level ( J:188598 )

♂ • decreased by 60% compared to control littermates

integument

abnormal coat/hair pigmentation ( J:153280 , J:188598 )

♂ • brown coat color with normal pigmentation of the skin and eyes (J:153280)

♂ (J:188598)