mortality/aging
• one of the four mice fed a high magnesium diet since gestation that survived weaning died within a week of weaning
|
• fewer than expected mice are detected at E16.5 to E18.5
|
• mice almost never survive to weaning
• when fed a high magnesium diet from gestation, survival at weaning is improved but fewer than expected mice are present
|
• fewer than expected mice are detected at E12.5
|
reproductive system
• homozygous mice fed a high magnesium diet from gestation fail to produce offspring when mated to each other but produce offspring when mated with heterozygous mice
|
nervous system
• mice that survive to late gestation or P1 exhibit a small hole in the head or neck
|
• in many mice
|
exencephaly
(
J:153718
)
• due to a defect in closure of the calvarium in one mouse
|
craniofacial
short snout
(
J:153718
)
embryo
• mice that survive to late gestation or P1 exhibit a small hole in the head or neck
|
• in many mice
|
growth/size/body
short snout
(
J:153718
)
• E16.5, E17.5, and E18.5
|
• E16.5, E17.5, and E18.5
|
skeleton
• in many mice
|