All Phenotypes Dclre1c<tm2.2Jpdv> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dclre1c^tm2.2Jpdv/Dclre1c^tm2.2Jpdv	B6.129S2-Dclre1c^tm2.2Jpdv	MGI:4366789
cn2	Dclre1c^tm2.1Jpdv/Dclre1c^tm2.2Jpdv Tg(Cr2-cre)3Cgn/0	involves: 129S2/SvPas * C57BL/6	MGI:4366790

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal mononuclear cell morphology ( J:153841 )

• mice exhibit a 6-fold reduction in blood mononuclear cells compared with wild-type mice

decreased thymocyte number ( J:153841 )

• 200-fold

absent immature B cells ( J:153841 )

• B220+IgM+ immature B cells are absent

arrested B cell differentiation ( J:153841 )

• at the proB-preB immature stage in the bone marrow

decreased double-positive T cell number ( J:153841 )

• almost none

arrested T cell differentiation ( J:153841 )

• at the CD4-CD8- double negative progenitor stage

decreased mature B cell number ( J:153841 )

decreased CD4-positive, alpha-beta T cell number ( J:153841 )

• almost none

decreased CD8-positive, alpha-beta T cell number ( J:153841 )

• almost none

decreased splenocyte number ( J:153841 )

• 30-fold

hematopoietic system

abnormal mononuclear cell morphology ( J:153841 )

• mice exhibit a 6-fold reduction in blood mononuclear cells compared with wild-type mice

decreased thymocyte number ( J:153841 )

• 200-fold

absent immature B cells ( J:153841 )

• B220+IgM+ immature B cells are absent

arrested B cell differentiation ( J:153841 )

• at the proB-preB immature stage in the bone marrow

decreased double-positive T cell number ( J:153841 )

• almost none

arrested T cell differentiation ( J:153841 )

• at the CD4-CD8- double negative progenitor stage

decreased mature B cell number ( J:153841 )

decreased CD4-positive, alpha-beta T cell number ( J:153841 )

• almost none

decreased CD8-positive, alpha-beta T cell number ( J:153841 )

• almost none

decreased splenocyte number ( J:153841 )

• 30-fold

endocrine/exocrine glands

decreased thymocyte number ( J:153841 )

• 200-fold

Allelic Composition	Dclre1c^tm2.1Jpdv/Dclre1c^tm2.2Jpdv Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclre1c^tm2.1Jpdv mutation (1 available); any Dclre1c mutation (31 available)
Dclre1c^tm2.2Jpdv mutation (0 available); any Dclre1c mutation (31 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:153841 )

N	• mice exhibit normal B cell development and Ig titers

abnormal class switch recombination ( J:153841 )

• class switching to IgG3 is decreased 23% compared to in wild-type mice

• in vivo Ig switching to IgA on KLH immunization is reduced 52% compared to in similarly treated wild-type mice

• class switch recombination junctions are altered compared to in wild-type mice

hematopoietic system

abnormal class switch recombination ( J:153841 )

• class switching to IgG3 is decreased 23% compared to in wild-type mice

• in vivo Ig switching to IgA on KLH immunization is reduced 52% compared to in similarly treated wild-type mice

• class switch recombination junctions are altered compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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