All Phenotypes Pole<tm1.1Bdp> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pole^tm1.1Bdp/Pole^tm1.1Bdp	B6.129-Pole^tm1.1Bdp	MGI:4366918
hm2	Pole^tm1.1Bdp/Pole^tm1.1Bdp	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:4366919
cx3	Pold1^tm1.1Bdp/Pold1^tm1.1Bdp Pole^tm1.1Bdp/Pole^tm1.1Bdp	B6.129-Pole^tm1.1Bdp Pold1^tm1.1Bdp	MGI:4366922
cx4	Mlh1^tm1Rak/Mlh1^tm1Rak Pole^tm1.1Bdp/Pole^tm1.1Bdp	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J	MGI:4366924
cx5	Msh2^tm1Rak/Msh2^tm1Rak Pole^tm1.1Bdp/Pole^tm1.1Bdp	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J	MGI:4366925

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:153684 )

• between 9 and 24 months mice succumb to cancer; median survival is 16 months

neoplasm

increased intestinal adenocarcinoma incidence ( J:153684 )

• 45% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice

increased colon adenocarcinoma incidence ( J:153684 )

• in one mouse

increased small intestine adenocarcinoma incidence ( J:153684 )

• in 13 of 15 mice with no evidence of metastasis

increased adenoma incidence ( J:153684 )

• one mouse developed a gastric adenoma

increased intestinal adenoma incidence ( J:153684 )

• 45% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice

increased lymphoma incidence ( J:153684 )

• 24% of mice develop nodal lymphomas compared with 6% of wild-type mice

increased histiocytic sarcoma incidence ( J:153684 )

• in 36% of mice compared with 22% of wild-type mice

increased lung tumor incidence ( J:153684 )

• 12% of mice develop lung adenomas and adenocarcinomas compared with 9% of wild-type mice

immune system

enlarged spleen ( J:153684 )

• in mice some mice

hematopoietic system

enlarged spleen ( J:153684 )

• in mice some mice

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:153684 )

• 45% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice

increased colon adenocarcinoma incidence ( J:153684 )

• in one mouse

increased small intestine adenocarcinoma incidence ( J:153684 )

• in 13 of 15 mice with no evidence of metastasis

increased intestinal adenoma incidence ( J:153684 )

• 45% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice

growth/size/body

enlarged spleen ( J:153684 )

• in mice some mice

respiratory system

increased lung tumor incidence ( J:153684 )

• 12% of mice develop lung adenomas and adenocarcinomas compared with 9% of wild-type mice

Allelic Composition	Pole^tm1.1Bdp/Pole^tm1.1Bdp
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pole^tm1.1Bdp mutation (0 available); any Pole mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:153684 )

neoplasm

increased tumor incidence ( J:153684 )

Allelic Composition	Pold1^tm1.1Bdp/Pold1^tm1.1Bdp Pole^tm1.1Bdp/Pole^tm1.1Bdp
Genetic Background	B6.129-Pole^tm1.1Bdp Pold1^tm1.1Bdp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pold1^tm1.1Bdp mutation (0 available); any Pold1 mutation (63 available)
Pole^tm1.1Bdp mutation (0 available); any Pole mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:153684 )

• mice die before 6 months

neoplasm

increased T cell derived lymphoma incidence ( J:153684 )

• in 82% of mice unlike in wild-type mice

increased skin tumor incidence ( J:153684 )

• 6% of mice develop tail skin squamous cell neoplasms (papilloma or carcinoma) unlike wild-type mice

integument

increased skin tumor incidence ( J:153684 )

• 6% of mice develop tail skin squamous cell neoplasms (papilloma or carcinoma) unlike wild-type mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:153684 )

• in 82% of mice unlike in wild-type mice

immune system

increased T cell derived lymphoma incidence ( J:153684 )

• in 82% of mice unlike in wild-type mice

hematopoietic system

increased T cell derived lymphoma incidence ( J:153684 )

• in 82% of mice unlike in wild-type mice

Allelic Composition	Mlh1^tm1Rak/Mlh1^tm1Rak Pole^tm1.1Bdp/Pole^tm1.1Bdp
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlh1^tm1Rak mutation (1 available); any Mlh1 mutation (44 available)
Pole^tm1.1Bdp mutation (0 available); any Pole mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality during fetal growth through weaning, complete penetrance ( J:153684 )

• mice are present in normal ratios up to E14.5; none are recovered at weaning

Allelic Composition	Msh2^tm1Rak/Msh2^tm1Rak Pole^tm1.1Bdp/Pole^tm1.1Bdp
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2^tm1Rak mutation (1 available); any Msh2 mutation (95 available)
Pole^tm1.1Bdp mutation (0 available); any Pole mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:153684 )

• no mice are present at weaning

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