Phenotypes associated with this allele

• Allele Symbol: Myd88^tm1Jcbr
• Allele Name: targeted mutation 1, Jens C Bruning
• Allele ID: MGI:4367063
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Myd88^tm1Jcbr/Myd88^tm1Jcbr Tg(Nes-cre)1Kln/0	B6.Cg-Myd88^tm1Jcbr Tg(Nes-cre)1Kln	MGI:4367075

Genotype
MGI:4367075

cn1

• Allelic Composition: Myd88^tm1Jcbr/Myd88^tm1Jcbr; Tg(Nes-cre)1Kln/0
• Genetic Background: B6.Cg-Myd88^tm1Jcbr Tg(Nes-cre)1Kln

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased energy expenditure ( J:153664 )

• at 12 weeks, male mice fed a high fat diet exhibit increased energy expenditure during the nighttime compared with similarly treated wild-type mice

decreased susceptibility to diet-induced obesity ( J:153664 )

• when fed a high fat diet, mice exhibit reduced weight gain and female mice exhibit no weight gain unlike similarly treated wild-type mice

abnormal glucose homeostasis ( J:153664 )

• mice fed a high fat diet exhibit a blunted impairment of glucose and insulin tolerance and insulin serum levels compared with similarly treated wild-type mice

decreased circulating insulin level ( J:153664 )

• in male mice fed a high fat diet compared with similarly treated wild-type mice

increased insulin sensitivity ( J:153664 )

• when fed a high fat diet, male mice exhibit improved insulin sensitivity compared with similarly treated wild-type mice

• when fed a high fat diet and treated with palmitate, mice exhibit a blunted insulin resistance compared with similarly treated wild-type mice

adipose tissue

decreased total body fat amount ( J:153664 )

• when fed a high fat diet, female mice exhibit a 24% in total fat mass compared with similarly treated wild-type mice

decreased fat cell size ( J:153664 )

• when fed a high fat diet compared with similarly treated wild-type mice

decreased epididymal fat pad weight ( J:153664 )

• slightly in male mice fed a high fat diet compared with similarly treated wild-type mice

abnormal parametrial fat pad morphology ( J:153664 )

• when fed a high fat diet, female mice exhibit a 60% reduction in parametiral fat mass compared with similarly treated wild-type mice

behavior/neurological

decreased food intake ( J:153664 )

• at 12 weeks, male mice fed a high fat diet exhibit reduced food intake compared with similarly treated wild-type mice

• female mice fed a high fat diet and treated with leptin exhibit decreased food intake unlike similarly treated wild-type mice

• male mice fed a high fat diet and treated with leptin exhibit a greater decrease in eating compared with similarly treated wild-type mice

decreased locomotor activity ( J:153664 )

• male mice fed a high fat diet exhibit decreased activity during the nighttime compared with similarly treated wild-type mice

growth/size/body

decreased body length ( J:153664 )

• when fed a high fat diet, mice fail to exhibit an increase in length unlike similarly treated wild-type mice

decreased susceptibility to diet-induced obesity ( J:153664 )

• when fed a high fat diet, mice exhibit reduced weight gain and female mice exhibit no weight gain unlike similarly treated wild-type mice