About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Meig1tm1.1Zzha
targeted mutation 1.1, Zhibing Zhang
MGI:4367077
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Meig1tm1.1Zzha/Meig1tm1.1Zzha
Tg(Prm-cre)58Og/0
involves: 129S1/SvImJ * 129S4/SvJae MGI:6852583
cn2
Meig1tm1.1Zzha/Meig1tm1.1Zzha
Tg(Amh-cre)8815Reb/0
involves: 129S1/SvImJ * FVB/N MGI:6852584
cn3
Meig1tm1.1Zzha/Meig1tm1.1Zzha
Tg(Hspa2-cre)1Eddy/0
involves: C57BL/6 * C57BL/6J MGI:6852580


Genotype
MGI:6852583
cn1
Allelic
Composition
Meig1tm1.1Zzha/Meig1tm1.1Zzha
Tg(Prm-cre)58Og/0
Genetic
Background
involves: 129S1/SvImJ * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meig1tm1.1Zzha mutation (0 available); any Meig1 mutation (14 available)
Tg(Prm-cre)58Og mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• all males are fertile and sire normal numbers of offspring
• testis weight to body weight and seminal vesicle weight to body weight ratios are normal
• epididymidal sperm count, testis as well as epididymal histology and sperm morphology are normal, and no reduction in sperm motility is observed




Genotype
MGI:6852584
cn2
Allelic
Composition
Meig1tm1.1Zzha/Meig1tm1.1Zzha
Tg(Amh-cre)8815Reb/0
Genetic
Background
involves: 129S1/SvImJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meig1tm1.1Zzha mutation (0 available); any Meig1 mutation (14 available)
Tg(Amh-cre)8815Reb mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• all males are fertile and sire normal numbers of offspring
• testis weight to body weight and seminal vesicle weight to body weight ratios are normal
• epididymidal sperm count, testis as well as epididymal histology and sperm morphology are normal, and no reduction in sperm motility is observed




Genotype
MGI:6852580
cn3
Allelic
Composition
Meig1tm1.1Zzha/Meig1tm1.1Zzha
Tg(Hspa2-cre)1Eddy/0
Genetic
Background
involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meig1tm1.1Zzha mutation (0 available); any Meig1 mutation (14 available)
Tg(Hspa2-cre)1Eddy mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• testis weight to body weight and seminal vesicle weight to body weight ratios are normal
• sperm axonemes and accessory structures appear disorganized
• "9 +2" axonemes are not present in the remaining flagella
• very few flagella are formed
• epididymidal sperm number is dramatically lower than that in control mice
• epididymides only contain debris and degenerating spermatozoa
• most of the remaining spermatozoa exhibit round or detached heads
• spermatids with enlarged redundant nuclear envelopes are observed
• spermatid tails are not formed properly, and the redundant nuclear envelope appears to be enlarged
• manchette structures are either disrupted or absent in condensing spermatids
• remaining epididymidal spermatozoa show no motility
• most spermatids fail to develop to the elongating stage
• epididymides only contain debris and degenerating spermatozoa
• all adult males are sterile

cellular
• sperm axonemes and accessory structures appear disorganized
• "9 +2" axonemes are not present in the remaining flagella
• very few flagella are formed
• epididymidal sperm number is dramatically lower than that in control mice
• epididymides only contain debris and degenerating spermatozoa
• most of the remaining spermatozoa exhibit round or detached heads
• spermatids with enlarged redundant nuclear envelopes are observed
• spermatid tails are not formed properly, and the redundant nuclear envelope appears to be enlarged
• manchette structures are either disrupted or absent in condensing spermatids
• remaining epididymidal spermatozoa show no motility





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/19/2024
MGI 6.24
The Jackson Laboratory