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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Meig1tm1.1Zzha
targeted mutation 1.1, Zhibing Zhang
MGI:4367077
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Meig1tm1.1Zzha/Meig1tm1.1Zzha
Tg(Prm-cre)58Og/0 		involves: 129S1/SvImJ * 129S4/SvJae MGI:6852583
cn2
 		Meig1tm1.1Zzha/Meig1tm1.1Zzha
Tg(Amh-cre)8815Reb/0 		involves: 129S1/SvImJ * FVB/N MGI:6852584
cn3
 		Meig1tm1.1Zzha/Meig1tm1.1Zzha
Tg(Hspa2-cre)1Eddy/0 		involves: C57BL/6 * C57BL/6J MGI:6852580


Genotype
MGI:6852583
cn1
Allelic
Composition		 Meig1tm1.1Zzha/Meig1tm1.1Zzha
Tg(Prm-cre)58Og/0
Genetic
Background		 involves: 129S1/SvImJ * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meig1tm1.1Zzha mutation (0 available); any Meig1 mutation (14 available)
Tg(Prm-cre)58Og mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:194944 )
N
• all males are fertile and sire normal numbers of offspring
• testis weight to body weight and seminal vesicle weight to body weight ratios are normal
• epididymidal sperm count, testis as well as epididymal histology and sperm morphology are normal, and no reduction in sperm motility is observed




Genotype
MGI:6852584
cn2
Allelic
Composition		 Meig1tm1.1Zzha/Meig1tm1.1Zzha
Tg(Amh-cre)8815Reb/0
Genetic
Background		 involves: 129S1/SvImJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meig1tm1.1Zzha mutation (0 available); any Meig1 mutation (14 available)
Tg(Amh-cre)8815Reb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:194944 )
N
• all males are fertile and sire normal numbers of offspring
• testis weight to body weight and seminal vesicle weight to body weight ratios are normal
• epididymidal sperm count, testis as well as epididymal histology and sperm morphology are normal, and no reduction in sperm motility is observed




Genotype
MGI:6852580
cn3
Allelic
Composition		 Meig1tm1.1Zzha/Meig1tm1.1Zzha
Tg(Hspa2-cre)1Eddy/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meig1tm1.1Zzha mutation (0 available); any Meig1 mutation (14 available)
Tg(Hspa2-cre)1Eddy mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:194944 )
N
• testis weight to body weight and seminal vesicle weight to body weight ratios are normal
abnormal sperm axoneme morphology ( J:194944 )
• sperm axonemes and accessory structures appear disorganized
• "9 +2" axonemes are not present in the remaining flagella
absent sperm flagellum ( J:194944 )
• very few flagella are formed
oligozoospermia ( J:194944 )
• epididymidal sperm number is dramatically lower than that in control mice
• epididymides only contain debris and degenerating spermatozoa
abnormal sperm head morphology ( J:194944 )
• most of the remaining spermatozoa exhibit round or detached heads
abnormal sperm nucleus morphology ( J:194944 )
• spermatids with enlarged redundant nuclear envelopes are observed
abnormal spermatid morphology ( J:194944 )
• spermatid tails are not formed properly, and the redundant nuclear envelope appears to be enlarged
abnormal manchette assembly ( J:194944 )
• manchette structures are either disrupted or absent in condensing spermatids
immotile sperm ( J:194944 )
• remaining epididymidal spermatozoa show no motility
arrest of spermiogenesis ( J:194944 )
• most spermatids fail to develop to the elongating stage
abnormal epididymis morphology ( J:194944 )
• epididymides only contain debris and degenerating spermatozoa
male infertility ( J:194944 )
• all adult males are sterile

cellular
abnormal sperm axoneme morphology ( J:194944 )
• sperm axonemes and accessory structures appear disorganized
• "9 +2" axonemes are not present in the remaining flagella
absent sperm flagellum ( J:194944 )
• very few flagella are formed
oligozoospermia ( J:194944 )
• epididymidal sperm number is dramatically lower than that in control mice
• epididymides only contain debris and degenerating spermatozoa
abnormal sperm head morphology ( J:194944 )
• most of the remaining spermatozoa exhibit round or detached heads
abnormal sperm nucleus morphology ( J:194944 )
• spermatids with enlarged redundant nuclear envelopes are observed
abnormal spermatid morphology ( J:194944 )
• spermatid tails are not formed properly, and the redundant nuclear envelope appears to be enlarged
abnormal manchette assembly ( J:194944 )
• manchette structures are either disrupted or absent in condensing spermatids
immotile sperm ( J:194944 )
• remaining epididymidal spermatozoa show no motility




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory