Phenotypes associated with this allele

• Allele Symbol: Meig1^tm1.2Zzha
• Allele Name: targeted mutation 1.2, Zhibing Zhang
• Allele ID: MGI:4367078
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Meig1^tm1.2Zzha/Meig1^tm1.2Zzha	Not Specified	MGI:4367081

Genotype
MGI:4367081

hm1

• Allelic Composition: Meig1^tm1.2Zzha/Meig1^tm1.2Zzha
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Sperm abnormalities in Meig1^tm1.2Zzha/Meig1^tm1.2Zzha mice

reproductive system

abnormal sperm axoneme morphology ( J:153677 )

♂ • disorganized without the normal 9 + 2 arrangement

absent sperm flagellum ( J:153677 )

♂

azoospermia ( J:153677 )

♂ • epididymides contain only debris and degenerating sperm unlike in wild-type mice

abnormal sperm head morphology ( J:153677 )

♂

asthenozoospermia ( J:153677 )

♂ • degenerating sperm do not exhibit motility unlike wild-type sperms

arrest of spermatogenesis ( J:153677 )

♂ • most spermatids only develop to steps 12 to 13 and a few to steps 14 to 15 unlike in wild-type mice

male infertility ( J:153677 )

♂

cellular

abnormal sperm axoneme morphology ( J:153677 )

♂ • disorganized without the normal 9 + 2 arrangement

absent sperm flagellum ( J:153677 )

♂

azoospermia ( J:153677 )

♂ • epididymides contain only debris and degenerating sperm unlike in wild-type mice

abnormal sperm head morphology ( J:153677 )

♂

asthenozoospermia ( J:153677 )

♂ • degenerating sperm do not exhibit motility unlike wild-type sperms