Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm2.1(sb11)Njen}
• Allele Name: targeted mutation 2.1, Nancy A Jenkins
• Allele ID: MGI:4367092
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm2.1(sb11)Njen/Gt(ROSA)26Sor^+ TgTn(sb-T2/Onc2)6070Njen/0	involves: 129 * C57BL/6 * C57BL/6J	MGI:4367199

Genotype
MGI:4367199

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm2.1(sb11)Njen}/Gt(ROSA)26Sor⁺; TgTn(sb-T2/Onc2)6070Njen/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:153656 )

• compared with Gt(ROSA)26Sor^{tm2(sb11)Njen} TgTn(sb-T2/Onc2)6070Njen and Gt(ROSA)26Sor^{tm2(sb11)Njen} Aicda^tm1(cre)Mnz TgTn(sb-T2/Onc2)6070Njen mice

neoplasm

increased hemolymphoid system tumor incidence ( J:153656 )

• mice develop hematopoietic tumors including T cell and erythoid tumors

• tumor latency is 59 days

increased T cell derived lymphoma incidence ( J:153656 )

• 67% of tumors are T cell lymphomas

increased leukemia incidence ( J:153656 )

• one mouse exhibited erythroid leukemia

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:153656 )

• 67% of tumors are T cell lymphomas

hematopoietic system

increased T cell derived lymphoma incidence ( J:153656 )

• 67% of tumors are T cell lymphomas

immune system

increased T cell derived lymphoma incidence ( J:153656 )

• 67% of tumors are T cell lymphomas