Analysis Tools|
Allele Symbol Allele Name Allele ID |
TgTn(sb-T2/Onc3)12740Njen transgenic transposon concatemer 12740, Nancy A Jenkins MGI:4367093 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 271 of 279 mice develop medulloblastoma compared with 54 of 139 control mice with decreased latency (2.5 months compared with 8 months)
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• 271 of 279 mice develop medulloblastoma compared with 54 of 139 control mice with decreased latency (2.5 months compared with 8 months)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in some mice with large cells, nuclear atypia and nuclear moulding typical of large cell/anaplastic histology
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• in some mice with large cells, nuclear atypia and nuclear moulding typical of large cell/anaplastic histology
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• compared with Gt(ROSA)26Sortm1(sb11)Njen mice
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• in one mouse
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• liver tumors metastasize to the lungs
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• 23 tumors in 62 with mice greater prevalent in male than female mice
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• 58 tumors in 62 mice with greater prevalent in male than female mice
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• 23 adenomas with multiple locations develop in 62 mice
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• 7 hemangiomas with multiple locations develop in 62 mice
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• in 11% of mice (7 tumors in 62 mice)
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• 3 tumors in 62 mice
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• 5 tumors in 62 mice
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• in one mouse
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• mice develop carcinomas in the colon (1 tumors in 62 mice), lung (3 in 62), mammary gland (5 in 62), salivary gland (1 in 62), preputial gland (12 in 62), parathyroid (1 in 62), and nasal cavity (1 in 62)
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• in one mouse
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• 3 tumors in 62 mice
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• one mouse developed a squamous cell carcinoma in the clitoral gland
• one mouse developed a squamous cell carcinoma in the salivary gland
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• 27 tumors in 62 mice
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• one mouse developed a melanoma
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• 2 sarcomas with multiple locations develop in 62 mice
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• 4 tumors in 62 mice
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• in one mouse
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• 27 tumors in 62 mice
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• in one mouse
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• 3 tumors in 62 mice
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• liver tumors metastasize to the lungs
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• 23 tumors in 62 with mice greater prevalent in male than female mice
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• 58 tumors in 62 mice with greater prevalent in male than female mice
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• 3 tumors in 62 mice
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• 3 tumors in 62 mice
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• 3 tumors in 62 mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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