All Phenotypes TgTn(sb-T2/Onc3)12740Njen MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ptch1^tm1Mps/Ptch1⁺ Tg(Atoh1-sb11)1Mtay/0 TgTn(sb-T2/Onc3)12740Njen/0	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J * ICR	MGI:5317025
cn2	Tg(Atoh1-sb11)1Mtay/0 TgTn(sb-T2/Onc3)12740Njen/0 Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C3H * C57BL/6J * ICR	MGI:5317026
cn3	Gt(ROSA)26Sor^{tm1(sb11)Njen}/Gt(ROSA)26Sor⁺ TgTn(sb-T2/Onc3)12740Njen/0	involves: C3H * C57BL/6J	MGI:4367200
cn4	Tg(Atoh1-sb11)1Mtay/0 TgTn(sb-T2/Onc3)12740Njen/0	involves: C3H * C57BL/6J * ICR	MGI:5317024

Allelic Composition	Ptch1^tm1Mps/Ptch1⁺ Tg(Atoh1-sb11)1Mtay/0 TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1^tm1Mps mutation (2 available); any Ptch1 mutation (115 available)
Tg(Atoh1-sb11)1Mtay mutation (0 available)
TgTn(sb-T2/Onc3)12740Njen mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased medulloblastoma incidence ( J:181542 )

• 271 of 279 mice develop medulloblastoma compared with 54 of 139 control mice with decreased latency (2.5 months compared with 8 months)

nervous system

increased medulloblastoma incidence ( J:181542 )

• 271 of 279 mice develop medulloblastoma compared with 54 of 139 control mice with decreased latency (2.5 months compared with 8 months)

Allelic Composition	Tg(Atoh1-sb11)1Mtay/0 TgTn(sb-T2/Onc3)12740Njen/0 Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * C3H * C57BL/6J * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Atoh1-sb11)1Mtay mutation (0 available)
TgTn(sb-T2/Onc3)12740Njen mutation (1 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased medulloblastoma incidence ( J:181542 )

• in some mice with large cells, nuclear atypia and nuclear moulding typical of large cell/anaplastic histology

nervous system

increased medulloblastoma incidence ( J:181542 )

• in some mice with large cells, nuclear atypia and nuclear moulding typical of large cell/anaplastic histology

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:153656 )

• compared with Gt(ROSA)26Sor^{tm1(sb11)Njen} mice

neoplasm

increased pheochromocytoma incidence ( J:153656 )

• in one mouse

increased liver tumor incidence ( J:153656 )

• liver tumors metastasize to the lungs

increased hepatocellular carcinoma incidence ( J:153656 )

• 23 tumors in 62 with mice greater prevalent in male than female mice

increased liver adenoma incidence ( J:153656 )

• 58 tumors in 62 mice with greater prevalent in male than female mice

increased adenoma incidence ( J:153656 )

• 23 adenomas with multiple locations develop in 62 mice

increased hemangioma incidence ( J:153656 )

• 7 hemangiomas with multiple locations develop in 62 mice

increased lymphoma incidence ( J:153656 )

• in 11% of mice (7 tumors in 62 mice)

increased T cell derived lymphoma incidence ( J:153656 )

• 3 tumors in 62 mice

increased B cell derived lymphoma incidence ( J:153656 )

• 5 tumors in 62 mice

increased blastoma incidence ( J:153656 )

• in one mouse

increased carcinoma incidence ( J:153656 )

• mice develop carcinomas in the colon (1 tumors in 62 mice), lung (3 in 62), mammary gland (5 in 62), salivary gland (1 in 62), preputial gland (12 in 62), parathyroid (1 in 62), and nasal cavity (1 in 62)

increased basal cell carcinoma incidence ( J:153656 )

• in one mouse

increased lung carcinoma incidence ( J:153656 )

• 3 tumors in 62 mice

increased squamous cell carcinoma incidence ( J:153656 )

• one mouse developed a squamous cell carcinoma in the clitoral gland

• one mouse developed a squamous cell carcinoma in the salivary gland

increased skin squamous cell carcinoma incidence ( J:153656 )

• 27 tumors in 62 mice

increased melanoma incidence ( J:153656 )

• one mouse developed a melanoma

increased sarcoma incidence ( J:153656 )

• 2 sarcomas with multiple locations develop in 62 mice

increased hemangiosarcoma incidence ( J:153656 )

• 4 tumors in 62 mice

integument

increased basal cell carcinoma incidence ( J:153656 )

• in one mouse

increased skin squamous cell carcinoma incidence ( J:153656 )

• 27 tumors in 62 mice

endocrine/exocrine glands

increased pheochromocytoma incidence ( J:153656 )

• in one mouse

increased T cell derived lymphoma incidence ( J:153656 )

• 3 tumors in 62 mice

liver/biliary system

increased liver tumor incidence ( J:153656 )

• liver tumors metastasize to the lungs

increased hepatocellular carcinoma incidence ( J:153656 )

• 23 tumors in 62 with mice greater prevalent in male than female mice

increased liver adenoma incidence ( J:153656 )

• 58 tumors in 62 mice with greater prevalent in male than female mice

respiratory system

increased lung carcinoma incidence ( J:153656 )

• 3 tumors in 62 mice

Allelic Composition	Tg(Atoh1-sb11)1Mtay/0 TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background	involves: C3H * C57BL/6J * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Atoh1-sb11)1Mtay mutation (0 available)
TgTn(sb-T2/Onc3)12740Njen mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:181542 )

N	• mice do not exhibit any tumors

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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