Phenotypes associated with this allele

• Allele Symbol: Foxo1^tm1.1Stlp
• Allele Name: targeted mutation 1.1, Stanford L Peng
• Allele ID: MGI:4367752
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Foxo1^tm1.1Stlp/Foxo1^tm1.1Stlp Tg(Lck-cre)1Cwi/0	involves: 129S4/SvJae	MGI:4367754

Genotype
MGI:4367754

cn1

• Allelic Composition: Foxo1^tm1.1Stlp/Foxo1^tm1.1Stlp; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased thymocyte apoptosis ( J:154205 )

• half as many CD4+ T cells undergo apoptosis compared to in wild-type mice

decreased T cell proliferation ( J:154205 )

• proliferation of single positive thymocytes stimulated with anti-CD3 and anti-CD3 plus anti-CD28 is almost half as much as in similarly treated wild-type cells

increased CD4-positive, alpha-beta T cell number ( J:154205 )

• CD4+ T cell thymocytes are increased compared to in wild-type mice

increased CD8-positive, alpha-beta T cell number ( J:154205 )

• CD8+ T cell thymocytes are increased compared to in wild-type mice

decreased T cell number ( J:154205 )

• spleen and lymph nodes have half as many T cells as in wild-type mice

decreased double-positive T cell number ( J:154205 )

• the percent of double positive thymocytes is slightly lower percent than in wild-type mice

decreased CD8-positive, alpha-beta T cell number ( J:154205 )

• the percentage of CD8+ T cells is decreased compared to in wild-type mice

abnormal single-positive T cell number ( J:154205 )

• the ratio of CD4+ to CD8+ peripheral T cells is skewed in favor of CD4+ T cells unlike in wild-type mice

small spleen ( J:154205 )

• with less than half of T cells

small lymphoid organs ( J:154205 )

• with less than half of T cells

hematopoietic system

decreased thymocyte apoptosis ( J:154205 )

• half as many CD4+ T cells undergo apoptosis compared to in wild-type mice

decreased T cell proliferation ( J:154205 )

• proliferation of single positive thymocytes stimulated with anti-CD3 and anti-CD3 plus anti-CD28 is almost half as much as in similarly treated wild-type cells

increased CD4-positive, alpha-beta T cell number ( J:154205 )

• CD4+ T cell thymocytes are increased compared to in wild-type mice

increased CD8-positive, alpha-beta T cell number ( J:154205 )

• CD8+ T cell thymocytes are increased compared to in wild-type mice

decreased T cell number ( J:154205 )

• spleen and lymph nodes have half as many T cells as in wild-type mice

decreased double-positive T cell number ( J:154205 )

• the percent of double positive thymocytes is slightly lower percent than in wild-type mice

decreased CD8-positive, alpha-beta T cell number ( J:154205 )

• the percentage of CD8+ T cells is decreased compared to in wild-type mice

abnormal single-positive T cell number ( J:154205 )

• the ratio of CD4+ to CD8+ peripheral T cells is skewed in favor of CD4+ T cells unlike in wild-type mice

small spleen ( J:154205 )

• with less than half of T cells

cellular

decreased thymocyte apoptosis ( J:154205 )

• half as many CD4+ T cells undergo apoptosis compared to in wild-type mice

decreased T cell proliferation ( J:154205 )

• proliferation of single positive thymocytes stimulated with anti-CD3 and anti-CD3 plus anti-CD28 is almost half as much as in similarly treated wild-type cells

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:154205 )

• half as many CD4+ T cells undergo apoptosis compared to in wild-type mice