All Phenotypes Kdr<tm1.1Jamb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kdr^tm1.1Jamb
targeted mutation 1.1, Jayakrishna Ambati
MGI:4367756

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kdr^tm1.1Jamb/Kdr^tm1.1Jamb	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:4367769
cn2	Kdr^tm1Jrt/Kdr^tm1.1Jamb Tg(CAG-cre/Esr1*)1Egwa/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:5052372
cn3	Kdr^tm1.1Jamb/Kdr^tm1.1Jamb Tg(Pax6-cre,GFP)1Pgr/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR	MGI:4367768
cn4	Kdr^tm1.1Jamb/Kdr^tm1.1Jamb Tg(KRT14-cre)1Efu/0	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:4367771

Allelic Composition	Kdr^tm1.1Jamb/Kdr^tm1.1Jamb
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1.1Jamb mutation (0 available); any Kdr mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased susceptibility to injury ( J:154336 )

• following intracorneal administration of a cre coding plasmid, mice exhibit an 161% increase in lymphangiogenesis but not hemangiogenesis in response to suture injury compared with mice injected with the empty vector

• mice treated intracorneally with a cre coding plasmid fail to exhibit a decrease in lymphangiogenesis when expression of soluble Kdr unlike similarly treated wild-type mice

immune system

abnormal lymphangiogenesis ( J:154336 )

• mice treated intracorneally with a cre coding plasmid fail to exhibit a decrease in lymphangiogenesis when expression of soluble Kdr unlike similarly treated wild-type mice

lymphatic vessel hyperplasia ( J:154336 )

• mice treated intracorneally with a cre coding plasmid fail to exhibit a decrease in lymphangiogenesis when expression of soluble Kdr unlike similarly treated wild-type mice

Allelic Composition	Kdr^tm1Jrt/Kdr^tm1.1Jamb Tg(CAG-cre/Esr1*)1Egwa/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1.1Jamb mutation (0 available); any Kdr mutation (74 available)
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (74 available)
Tg(CAG-cre/Esr1*)1Egwa mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Suppression of of extraretinal vascular outgrowth in ischemic Kdr^tm1.1Jamb/Kdr^tm1Jrt Tg(CAG-cre/Esr1*)1Egwa/0 retinas

cardiovascular system

abnormal induced retina neovascularization ( J:173943 )

• tamoxifen-treated mice exhibit decreased extraretinal vascular outgrowth in ischemic retinas compared with control mice

vision/eye

abnormal induced retina neovascularization ( J:173943 )

• tamoxifen-treated mice exhibit decreased extraretinal vascular outgrowth in ischemic retinas compared with control mice

Allelic Composition	Kdr^tm1.1Jamb/Kdr^tm1.1Jamb Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1.1Jamb mutation (0 available); any Kdr mutation (74 available)
Tg(Pax6-cre,GFP)1Pgr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal cornea morphology ( J:154336 )

• at P0, corneas are densely covered with lymphatic vessels unlike in wild-type mice

• however, mice exhibit normal limbal blood vessels and corneal hemangiogenesis in response to suture injury

immune system

abnormal lymphatic vessel morphology ( J:154336 )

• hyperplastic lymphatic vessels in the cornea lack erythocytes, do not have a continuous basement membrane, and containing partly overlapping thin endothelial cells free of pericyte coverage unlike wild-type lymphatic vessels

lymphatic vessel hyperplasia ( J:154336 )

• at P0, corneas are densely covered with lymphatic vessels unlike in wild-type mice

cellular

abnormal basement membrane morphology ( J:154336 )

• hyperplastic lymphatic vessels in the cornea do not have a continuous basement membrane unlike wild-type lymphatic vessels

Allelic Composition	Kdr^tm1.1Jamb/Kdr^tm1.1Jamb Tg(KRT14-cre)1Efu/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1.1Jamb mutation (0 available); any Kdr mutation (74 available)
Tg(KRT14-cre)1Efu mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

lymphatic vessel hyperplasia ( J:154336 )

• skin lymphatic vessels are dilated and hyperplastic compared to in wild-type mice

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