Analysis Tools
behavior/neurological
| N |
• mice exhibit normal motor coordination, motor learning, balance, muscular tonus, and anxiety-related behavior
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• in a second session, mice spend more time exploring a familiar object and less time exploring a novel object compared with wild-type mice
• however, novel object exploration during the initial session is normal
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• in a second session 24 hours after the first, mice fail habituate and exhibit a 21% increase in distance traveled compared with wild-type mice
• however, activity during the initial session in an open field is normal
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• during the learning phase of a Morris water maze, mice exhibit enhanced spatial learning compared with wild-type mice
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• mice exhibit reduced spontaneous alternation in a Y-maze test compared with wild-type mice
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• in a second session 24 hours after the first, mice fail habituate and exhibit a 44% increase in rearing compared with wild-type mice
• however, activity during the initial session in an open field is normal
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nervous system
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• mice exhibit larger and longer-lasting long term potentiation compared with wild-type mice
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homeostasis/metabolism
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• homocysteine levels are decreased compared to in wild-type mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Down syndrome | DOID:14250 |
OMIM:190685 |
J:154298 | |
