Phenotypes associated with this allele

• Allele Symbol: Ffar2^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:4367910
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ffar2^tm1Dgen/Ffar2^tm1Dgen	involves: C57BL/6	MGI:4367988

Genotype
MGI:4367988

hm1

• Allelic Composition: Ffar2^tm1Dgen/Ffar2^tm1Dgen
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:153951 )

• in DSS-treated mice

immune system

increased susceptibility to induced colitis ( J:153951 )

• during the acute phase after DSS treatment, mice exhibit increased inflammatory response with increased mortality, increased weight loss, reduced colon length, and increased daily activity index compared with similarly treated wild-type mice

• mice exhibit no protection from DSS-induced colitis when treated with acetate unlike similarly treated wild-type mice

• TNBS (trinitrobenzoic sulphonic acid)-treated mice exhibit increased colitis with decreased colon length and increased colonic damage and CD44+IL17+ T cells accumulation compared with similarly treated wild-type mice

• transplantation of bone marrow confers increased susceptibility to DSS-induced colitis to wild-type mice

increased T cell number ( J:153951 )

• CD44+IL17+ T cells are increased in the mesenteric lymph nodes of TNBS-treated mice

abnormal granulocyte physiology ( J:153951 )

• granulocytes produce more reactive oxygen species and myeloperoxidase activity compared with wild-type cells

abnormal neutrophil physiology ( J:153951 )

• neutrophils fail to exhibit a robust calcium flux when treated with acetate unlike similarly treated wild-type mice

• neutrophils exhibit increased chemotaxis in response to fMLP and C5a compared with similarly treated wild-type cells

• recruitment of neutrophils from Staphylococcus aureus injected mice exhibit greater recruitment compared with cells from similarly treated wild-type mice

impaired neutrophil chemotaxis ( J:153951 )

• neutrophils exhibit a low chemotactic index in response to very high concentrations of acetate unlike similarly treated wild-type mice

impaired neutrophil phagocytosis ( J:153951 )

• neutrophils stimulated with short chain fatty acids exhibit reduced release of reactive oxygen species and phagocytic activity compared with similarly treated wild-type mice

increased susceptibility to induced arthritis ( J:153951 )

• while mice exhibit a slight delay in the development of induced arthritis, by day 11 mice develop more severe arthritis compared with similarly treated wild-type mice

lung inflammation ( J:153951 )

• mice exhibit increased response to ovalbumin-induced asthma with increased number of inflammatory cells in the bronchoalveolar lavage and lung tissue compared with wild-type mice

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:153951 )

• in DSS-treated mice

digestive/alimentary system

increased susceptibility to induced colitis ( J:153951 )

• during the acute phase after DSS treatment, mice exhibit increased inflammatory response with increased mortality, increased weight loss, reduced colon length, and increased daily activity index compared with similarly treated wild-type mice

• mice exhibit no protection from DSS-induced colitis when treated with acetate unlike similarly treated wild-type mice

• TNBS (trinitrobenzoic sulphonic acid)-treated mice exhibit increased colitis with decreased colon length and increased colonic damage and CD44+IL17+ T cells accumulation compared with similarly treated wild-type mice

• transplantation of bone marrow confers increased susceptibility to DSS-induced colitis to wild-type mice

respiratory system

lung inflammation ( J:153951 )

• mice exhibit increased response to ovalbumin-induced asthma with increased number of inflammatory cells in the bronchoalveolar lavage and lung tissue compared with wild-type mice

skeleton

increased susceptibility to induced arthritis ( J:153951 )

• while mice exhibit a slight delay in the development of induced arthritis, by day 11 mice develop more severe arthritis compared with similarly treated wild-type mice

hematopoietic system

increased T cell number ( J:153951 )

• CD44+IL17+ T cells are increased in the mesenteric lymph nodes of TNBS-treated mice

abnormal granulocyte physiology ( J:153951 )

• granulocytes produce more reactive oxygen species and myeloperoxidase activity compared with wild-type cells

abnormal neutrophil physiology ( J:153951 )

• neutrophils fail to exhibit a robust calcium flux when treated with acetate unlike similarly treated wild-type mice

• neutrophils exhibit increased chemotaxis in response to fMLP and C5a compared with similarly treated wild-type cells

• recruitment of neutrophils from Staphylococcus aureus injected mice exhibit greater recruitment compared with cells from similarly treated wild-type mice

impaired neutrophil chemotaxis ( J:153951 )

• neutrophils exhibit a low chemotactic index in response to very high concentrations of acetate unlike similarly treated wild-type mice

impaired neutrophil phagocytosis ( J:153951 )

• neutrophils stimulated with short chain fatty acids exhibit reduced release of reactive oxygen species and phagocytic activity compared with similarly treated wild-type mice

cellular

impaired neutrophil chemotaxis ( J:153951 )

• neutrophils exhibit a low chemotactic index in response to very high concentrations of acetate unlike similarly treated wild-type mice

impaired neutrophil phagocytosis ( J:153951 )

• neutrophils stimulated with short chain fatty acids exhibit reduced release of reactive oxygen species and phagocytic activity compared with similarly treated wild-type mice