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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbx21duane
Duane
MGI:4367995
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tbx21duane/Tbx21duane C57BL/6-Tbx21duane MGI:4368003


Genotype
MGI:4368003
hm1
Allelic
Composition		 Tbx21duane/Tbx21duane
Genetic
Background		 C57BL/6-Tbx21duane
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx21duane mutation (4 available); any Tbx21 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell differentiation ( J:154069 )
• NK cells exhibit an immature phenotype unlike in wild-type mice
• NK cells accumulate in lymph nodes due to defective egression
• in reconstitution experiments, derived NK cells accumulate in the peripheral lymph nodes due to defective egression
decreased NK cell number ( J:154069 )
• the percent of NK cells in the blood, spleen, and liver is lower than in wild-type mice
increased NK cell number ( J:154069 )
• the frequency of NK cells in the peripheral lymph nodes and bone marrow is increased compared to in wild-type mice
• NK cells accumulate in lymph nodes due to defective egression
absent NK T cells ( J:154069 )
• mice exhibit a near complete absence of invariant natural killer T cells unlike in wild-type mice

hematopoietic system
abnormal NK cell differentiation ( J:154069 )
• NK cells exhibit an immature phenotype unlike in wild-type mice
• NK cells accumulate in lymph nodes due to defective egression
• in reconstitution experiments, derived NK cells accumulate in the peripheral lymph nodes due to defective egression
decreased NK cell number ( J:154069 )
• the percent of NK cells in the blood, spleen, and liver is lower than in wild-type mice
increased NK cell number ( J:154069 )
• the frequency of NK cells in the peripheral lymph nodes and bone marrow is increased compared to in wild-type mice
• NK cells accumulate in lymph nodes due to defective egression
absent NK T cells ( J:154069 )
• mice exhibit a near complete absence of invariant natural killer T cells unlike in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory