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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		S1pr5tm1Jch
targeted mutation 1, Jerold Chun
MGI:4368002
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		S1pr5tm1Jch/S1pr5tm1Jch involves: 129P2/OlaHsd * C57BL/6 MGI:4368004


Genotype
MGI:4368004
hm1
Allelic
Composition		 S1pr5tm1Jch/S1pr5tm1Jch
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
S1pr5tm1Jch mutation (0 available); any S1pr5 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal NK cell differentiation ( J:154069 )
• in reconstitution experiments, derived NK cells accumulate in the lymph nodes and bone marrow indicating a reduction in NK cell egression from the lymph nodes and bone marrow compared to when wild-type bone marrow is used

immune system
abnormal NK cell differentiation ( J:154069 )
• in reconstitution experiments, derived NK cells accumulate in the lymph nodes and bone marrow indicating a reduction in NK cell egression from the lymph nodes and bone marrow compared to when wild-type bone marrow is used




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory