Phenotypes associated with this allele

• Allele Symbol: Ilk^tm8.1Ref
• Allele Name: targeted mutation 8.1, Reinhard Fassler
• Allele ID: MGI:4368012
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ilk^tm8.1Ref/Ilk^tm8.1Ref	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:4397489

Genotype
MGI:4397489

hm1

• Allelic Composition: Ilk^tm8.1Ref/Ilk^tm8.1Ref
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:154054 )

• all mice die shortly after birth

renal/urinary system

decreased kidney collecting duct number ( J:154054 )

• reduced in number in the kidneys that do develop

renal hypoplasia ( J:154054 )

• 3% of mice exhibit dysgenic or hypoplastic kidneys

decreased nephron number ( J:154054 )

• reduced nephron number in the kidneys that do develop

absent kidney ( J:154054 )

• in 70% of mice

single kidney ( J:154054 )

• in 27% of mice

absent ureter ( J:154054 )

• in 8% of mice lacking one or both kidneys

growth/size/body

decreased birth body size ( J:154054 )

behavior/neurological

aphagia ( J:154054 )

• mice fail to eat at birth

hunched posture ( J:154054 )

• at birth, mice exhibit a bent body posture unlike wild-type mice

cardiovascular system

cardiovascular system phenotype ( J:154054 )

N • mice do not exhibit heart defects

integument

integument phenotype ( J:154054 )

N • mice do not exhibit skin defects

pallor ( J:154054 )

• at birth