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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		NipblGt(EUCE313f02)Hmgu
gene trap EUCE313f02, Helmholtz Zentrum Muenchen GmbH
MGI:4374347
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		NipblGt(EUCE313f02)Hmgu/Nipbl+ involves: 129P2/OlaHsd * CD-1 MGI:7492170
cn2
 		NipblGt(EUCE313f02)Hmgu/Nipbl+
Sox17tm2.1(icre)Heli/Sox17+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CD-1 MGI:7492242
cn3
 		NipblGt(EUCE313f02)Hmgu/Nipbl+
Tg(Nanog-cre)#Vlcg/0 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac * CD-1 MGI:7492240
cn4
 		NipblGt(EUCE313f02)Hmgu/Nipbl+
Tg(Tnnt2-cre)5Blh/0 		involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2 MGI:7492241


Genotype
MGI:7492170
ht1
Allelic
Composition		 NipblGt(EUCE313f02)Hmgu/Nipbl+
Genetic
Background		 involves: 129P2/OlaHsd * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NipblGt(EUCE313f02)Hmgu mutation (0 available); any Nipbl mutation (124 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:236978 )
• only 4% of pups survive to weaning

cardiovascular system
ostium secundum atrial septal defect ( J:236978 )
• at E17.5 in about 30% of mice
• however, no ventricular septal defect, arterial stenosis or obvious abnormalities of ventricular wall thickness are seen
small heart ( J:236978 )
• in proportion to decrease in body size

growth/size/body
decreased body size ( J:236978 )




Genotype
MGI:7492242
cn2
Allelic
Composition		 NipblGt(EUCE313f02)Hmgu/Nipbl+
Sox17tm2.1(icre)Heli/Sox17+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NipblGt(EUCE313f02)Hmgu mutation (0 available); any Nipbl mutation (124 available)
Sox17tm2.1(icre)Heli mutation (0 available); any Sox17 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:236978 )
• 5% of hearts show an atrial septal defect, statistically indistinguishable from wild-type
small heart ( J:236978 )
• correlates to body size

growth/size/body
decreased body size ( J:236978 )




Genotype
MGI:7492240
cn3
Allelic
Composition		 NipblGt(EUCE313f02)Hmgu/Nipbl+
Tg(Nanog-cre)#Vlcg/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NipblGt(EUCE313f02)Hmgu mutation (0 available); any Nipbl mutation (124 available)
Tg(Nanog-cre)#Vlcg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:236978 )
N
• hearts lack atrial septal defects and are indistinguishable from wild-type




Genotype
MGI:7492241
cn4
Allelic
Composition		 NipblGt(EUCE313f02)Hmgu/Nipbl+
Tg(Tnnt2-cre)5Blh/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NipblGt(EUCE313f02)Hmgu mutation (0 available); any Nipbl mutation (124 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:236978 )
• only a single heart showed an atrial septal defect, statistically indistinguishable from wild-type
small heart ( J:236978 )
• correlates to body size

growth/size/body
decreased body size ( J:236978 )




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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory