Phenotypes associated with this allele

• Allele Symbol: Tigar^{Gt(EUCE0047g05)Hmgu}
• Allele Name: gene trap EUCE0047g05, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:4391656
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tigar^Gt(EUCE0047g05)Hmgu/Tigar^Gt(EUCE0047g05)Hmgu	involves: 129P2/OlaHsd	MGI:5522715
cn2	Tigar^Gt(EUCE0047g05)Hmgu/Tigar^Gt(EUCE0047g05)Hmgu Apc^tm1Tno/Apc^tm1Tno Lgr5^tm1(cre/ERT2)Cle/Lgr5^+	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:5522716

Genotype
MGI:5522715

hm1

• Allelic Composition: Tigar^{Gt(EUCE0047g05)Hmgu}/Tigar^{Gt(EUCE0047g05)Hmgu}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198650 )

• some DSS-treated mice succumb 1 day earlier than wild-type mice

digestive/alimentary system

abnormal small intestinal crypt cell physiology ( J:198650 )

• following gamma ray exposure or cisplatin, mice exhibit reduced size and number of regenerating crypts with reduced cellular proliferation and increased apoptosis compared with wild-type mice

• oxythiamine treatment exacerbates crypt growth defects and somewhat impedes NAC rescue

• however, crypt formation in cultures can be restored by treatment with N-acetyl L-cysteine (NAC) and nucleosides

increased small intestinal crypt cell apoptosis ( J:198650 )

• increased following gamma ray or cisplatin exposure

abnormal small intestinal crypt cell proliferation ( J:198650 )

• reduced following gamma ray, cisplatin or DSS exposure

increased susceptibility to induced colitis ( J:198650 )

• DSS-treated mice exhibit impaired colon regeneration with reduced cell proliferation, increased reactive oxygen species production and earlier lethality compared with wild-type mice

• however, some mice recover from DSS exposure

immune system

increased susceptibility to induced colitis ( J:198650 )

• DSS-treated mice exhibit impaired colon regeneration with reduced cell proliferation, increased reactive oxygen species production and earlier lethality compared with wild-type mice

• however, some mice recover from DSS exposure

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198650 )

• some DSS-treated mice succumb 1 day earlier than wild-type mice

cellular

increased cellular sensitivity to alkylating agents ( J:198650 )

• following cisplatin exposure, mice exhibit reduced size and number of regenerating crypts with reduced cellular proliferation and increased apoptosis compared with wild-type mice

increased cellular sensitivity to gamma-irradiation ( J:198650 )

• following gamma ray exposure, mice exhibit reduced size and number of regenerating crypts with reduced cellular proliferation and increased apoptosis compared with wild-type mice

increased small intestinal crypt cell apoptosis ( J:198650 )

• increased following gamma ray or cisplatin exposure

abnormal small intestinal crypt cell proliferation ( J:198650 )

• reduced following gamma ray, cisplatin or DSS exposure

oxidative stress ( J:198650 )

• in intestinal tissue following gamma ray, cisplatin or DSS exposure

Genotype
MGI:5522716

cn2

• Allelic Composition: Tigar^{Gt(EUCE0047g05)Hmgu}/Tigar^{Gt(EUCE0047g05)Hmgu}; Apc^tm1Tno/Apc^tm1Tno; Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:198650 )

• in tamoxifen-treated mice compared with Apc^tm1Tno/Apc^tm1Tno Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ mice

neoplasm

decreased tumor growth/size ( J:198650 )

• tamoxifen-treated mice exhibit a reduced total tumor burden and average tumor size of abnormally proliferating adenomas in the small intestine and reduced size, but not number, of colon adenomas due to reduced proliferation and increased reactive oxygen species damage compared with Apc^tm1Tno/Apc^tm1Tno Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ mice