All Phenotypes Tg(Col10a1-Tg*L2263P)1Rpbh MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Col10a1-TgL2263P)1Rpbh/Tg(Col10a1-TgL2263P)1Rpbh	Not Specified	MGI:4397577
tg2	Tg(Col10a1-Tg*L2263P)1Rpbh/0	Not Specified	MGI:4397578

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

short femur ( J:154052 )

• shorter femurs at 3 and 6 weeks of age

• long bone growth is indistinguishable from that of the age-matched controls by 10 weeks of age

skeleton

decreased osteoclast cell number ( J:154052 )

• fewer osteoclasts localize to the vascular invasion front of the growth plate

short femur ( J:154052 )

• shorter femurs at 3 and 6 weeks of age

• long bone growth is indistinguishable from that of the age-matched controls by 10 weeks of age

increased width of hypertrophic chondrocyte zone ( J:154052 )

• expanded hypertrophic zones of the growth plates (80% thicker) in new born mice

• expanded hypertrophic zones of the growth plates (4 fold) at 3 weeks of age

• the hypertrophic zone expansion is resolved at 6 weeks of age

abnormal pelvic girdle bone morphology ( J:154052 )

• slight distortion of the pelvis

cellular

increased endoplasmic reticulum stress ( J:154052 )

• increased endoplasmic reticulum stress in hypertrophic chondrocytes

• induced unfolded protein response

hematopoietic system

decreased osteoclast cell number ( J:154052 )

• fewer osteoclasts localize to the vascular invasion front of the growth plate

immune system

decreased osteoclast cell number ( J:154052 )

• fewer osteoclasts localize to the vascular invasion front of the growth plate

Allelic Composition	Tg(Col10a1-Tg*L2263P)1Rpbh/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Characterization of the Tg(Col10a1-Tg*L2263P)1Rpbh/Tg(Col10a1-Tg*L2263P)1Rpbh and Tg(Col10a1-Tg*L2263P)1Rpbh/0 mouse phenotype

limbs/digits/tail

short femur ( J:154052 )

• shorter femurs at 3 and 6 weeks of age

• long bone growth is indistinguishable from that of the age-matched controls by 10 weeks of age

skeleton

decreased osteoclast cell number ( J:154052 )

• fewer osteoclasts localize to the vascular invasion front of the growth plate

short femur ( J:154052 )

• shorter femurs at 3 and 6 weeks of age

• long bone growth is indistinguishable from that of the age-matched controls by 10 weeks of age

increased width of hypertrophic chondrocyte zone ( J:154052 )

• expanded hypertrophic zones of the growth plates (3 fold) at 3 weeks of age

• the hypertrophic zone expansion is resolved at 6 weeks of age

abnormal pelvic girdle bone morphology ( J:154052 )

• slight distortion of the pelvis

cellular

increased endoplasmic reticulum stress ( J:154052 )

• increased endoplasmic reticulum stress in hypertrophic chondrocytes

• induced unfolded protein response

hematopoietic system

decreased osteoclast cell number ( J:154052 )

• fewer osteoclasts localize to the vascular invasion front of the growth plate

immune system

decreased osteoclast cell number ( J:154052 )

• fewer osteoclasts localize to the vascular invasion front of the growth plate

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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