About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gtsf1tm1Miya
targeted mutation 1, Jun-ichi Miyazaki
MGI:4397586
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gtsf1tm1Miya/Gtsf1tm1Miya involves: 129P2/OlaHsd * C57BL/6 MGI:4397588


Genotype
MGI:4397588
hm1
Allelic
Composition
Gtsf1tm1Miya/Gtsf1tm1Miya
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtsf1tm1Miya mutation (1 available); any Gtsf1 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• female mice exhibit normal ovary morphology and fertility
• at 5 months, male mice exhibit a depletion of meiotic cells, post-meiotic cells, and mature sperm cells compared with wild-type mice
• beginning at P14 and more prevalent at P18
• at leptotene with increased staining for double strand breaks
• beginning at P14 and more prevalent at P18
• despite normal copulation

endocrine/exocrine glands

cellular
• at 5 months, male mice exhibit a depletion of meiotic cells, post-meiotic cells, and mature sperm cells compared with wild-type mice
• beginning at P14 and more prevalent at P18
• at leptotene with increased staining for double strand breaks
• beginning at P14 and more prevalent at P18





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory