Phenotypes associated with this allele

• Allele Symbol: Pdcd1^tm1.1Shr
• Allele Name: targeted mutation 1.1, Arlene H Sharpe
• Allele ID: MGI:4397682
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdcd1^tm1.1Shr/Pdcd1^tm1.1Shr	involves: C57BL/6	MGI:4397686
cx2	Pdcd1^tm1.1Shr/Pdcd1^tm1.1Shr Tg(TcraTcrb)1100Mjb/0	involves: C57BL/6	MGI:4397687

Genotype
MGI:4397686

hm1

• Allelic Composition: Pdcd1^tm1.1Shr/Pdcd1^tm1.1Shr
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B-1 B cell number ( J:153040 )

• small decrease

increased regulatory T cell number ( J:153040 )

• modest increase in the thymic, but not peripheral, compartment

vision/eye

increased retina ganglion cell number ( J:154546 )

• at P2 and P4, the number of Brn3a (Pou4f1)+ retinal ganglion cells in the ganglion cell layer is increased compared to in wild-type mice

• however, the number of Brn3a+ retinal ganglion cells is normal by P9

hematopoietic system

decreased B-1 B cell number ( J:153040 )

• small decrease

increased regulatory T cell number ( J:153040 )

• modest increase in the thymic, but not peripheral, compartment

nervous system

increased retina ganglion cell number ( J:154546 )

• at P2 and P4, the number of Brn3a (Pou4f1)+ retinal ganglion cells in the ganglion cell layer is increased compared to in wild-type mice

• however, the number of Brn3a+ retinal ganglion cells is normal by P9

Genotype
MGI:4397687

cx2

• Allelic Composition: Pdcd1^tm1.1Shr/Pdcd1^tm1.1Shr; Tg(TcraTcrb)1100Mjb/0
• Genetic Background: involves: C57BL/6

immune system

decreased T cell proliferation ( J:153040 )

• following adoptive transfer, naive CD8+ T cells exhibit no proliferation in RIP-ova^low recipients unlike similarly treated wild-type cells

increased T cell proliferation ( J:153040 )

• following adoptive transfer, T cells exhibit increased cell intrinsic proliferation in RIP-ova^high recipients unlike similarly treated wild-type cells

pancreas inflammation ( J:153040 )

• following adoptive transfer, CD8+ T cells induce peri-ductal infiltrates and vasculitis within the pancreas in RIP-ova^high recipients unlike similarly treated wild-type cells

insulitis ( J:153040 )

• following adoptive transfer, CD8+ T cells induce severe insulitis in RIP-ova^high recipients unlike similarly treated wild-type cells

abnormal immune tolerance ( J:153040 )

• following adoptive transfer, CD8+ T cells fail to undergo cross-tolerization when transplanted into RIP-ova^high recipients unlike similarly treated wild-type cells

increased susceptibility to autoimmune diabetes ( J:153040 )

• following adoptive transfer, CD8+ T cells induce diabetes in RIP-ova^high or RIP-ova^low recipients unlike similarly treated wild-type cells

cardiovascular system

vascular inflammation ( J:153040 )

• following adoptive transfer, CD8+ T cells induce vasculitis within the pancreas in RIP-ova^high recipients unlike similarly treated wild-type cells

endocrine/exocrine glands

pancreas inflammation ( J:153040 )

• following adoptive transfer, CD8+ T cells induce peri-ductal infiltrates and vasculitis within the pancreas in RIP-ova^high recipients unlike similarly treated wild-type cells

insulitis ( J:153040 )

• following adoptive transfer, CD8+ T cells induce severe insulitis in RIP-ova^high recipients unlike similarly treated wild-type cells

hematopoietic system

decreased T cell proliferation ( J:153040 )

• following adoptive transfer, naive CD8+ T cells exhibit no proliferation in RIP-ova^low recipients unlike similarly treated wild-type cells

increased T cell proliferation ( J:153040 )

• following adoptive transfer, T cells exhibit increased cell intrinsic proliferation in RIP-ova^high recipients unlike similarly treated wild-type cells

cellular

decreased T cell proliferation ( J:153040 )

• following adoptive transfer, naive CD8+ T cells exhibit no proliferation in RIP-ova^low recipients unlike similarly treated wild-type cells

increased T cell proliferation ( J:153040 )

• following adoptive transfer, T cells exhibit increased cell intrinsic proliferation in RIP-ova^high recipients unlike similarly treated wild-type cells