Phenotypes associated with this allele

• Allele Symbol: Tg(Sox2-cre/ERT2)1Skn
• Allele Name: transgene insertion 1, Silvia K Nicolis
• Allele ID: MGI:4397776
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sox2^tm4.1Skn/Sox2^tm4.1Skn Tg(Sox2-cre/ERT2)1Skn/0	involves: 129S1/Sv * 129S4/SvJae	MGI:4397784

Genotype
MGI:4397784

cn1

• Allelic Composition: Sox2^tm4.1Skn/Sox2^tm4.1Skn; Tg(Sox2-cre/ERT2)1Skn/0
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:154650 )

• following tamoxifen treatment, the numbers of SOX2/GFAP+ cells with radial glial morphology and GFAP/nestin+ cells at the base of the dentate gyrus are reduced 40% compared to in wild-type mice or untreated controls

abnormal radial glial cell morphology ( J:154650 )

• following tamoxifen treatment, the numbers of SOX2/GFAP+ cells with radial glial morphology and GFAP/nestin+ cells at the base of the dentate gyrus are reduced 40% compared to in wild-type mice or untreated controls

abnormal neuronal precursor proliferation ( J:154650 )

• following tamoxifen treatment, proliferation of neuronal precursor cells downstream of stem cells is decreased compared to in wild-type mice or untreated controls

• following tamoxifen treatment, doublecortin+ cells exhibit reduced proliferation compared to in wild-type mice but to a lesser extent than earlier precursors

cellular

abnormal neuron differentiation ( J:154650 )

• following tamoxifen treatment, the numbers of SOX2/GFAP+ cells with radial glial morphology and GFAP/nestin+ cells at the base of the dentate gyrus are reduced 40% compared to in wild-type mice or untreated controls

abnormal radial glial cell morphology ( J:154650 )

• following tamoxifen treatment, the numbers of SOX2/GFAP+ cells with radial glial morphology and GFAP/nestin+ cells at the base of the dentate gyrus are reduced 40% compared to in wild-type mice or untreated controls

abnormal neuronal precursor proliferation ( J:154650 )

• following tamoxifen treatment, proliferation of neuronal precursor cells downstream of stem cells is decreased compared to in wild-type mice or untreated controls

• following tamoxifen treatment, doublecortin+ cells exhibit reduced proliferation compared to in wild-type mice but to a lesser extent than earlier precursors