About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Epha4tm2Kldr
targeted mutation 2, Klas Kullander
MGI:4398683
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Epha4tm2Kldr/Epha4tm2Kldr
Tg(Pgk1-cre)1Lni/0 		involves: BALB/c * C57BL/6 MGI:4398699
cn2
 		Epha4tm2Kldr/Epha4tm2.1Kldr
Grik4tm1.1(cre)Slab/Grik4+ 		involves: C57BL/6 MGI:4398696


Genotype
MGI:4398699
cn1
Allelic
Composition		 Epha4tm2Kldr/Epha4tm2Kldr
Tg(Pgk1-cre)1Lni/0
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm2Kldr mutation (0 available); any Epha4 mutation (67 available)
Tg(Pgk1-cre)1Lni mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal anterior commissure morphology ( J:154648 )
• the anterior commissure does not form in its normal location
abnormal spinal cord dorsal column morphology ( J:154648 )
• the ventral part of the dorsal funiculus is reduced and the distance between the dorsal funiculus and the central canal is increased compared to in Epha4tm2Kldr control mice

behavior/neurological
abnormal gait ( J:154648 )
• mice exhibit a hopping gait unlike Epha4tm2Kldr control mice




Genotype
MGI:4398696
cn2
Allelic
Composition		 Epha4tm2Kldr/Epha4tm2.1Kldr
Grik4tm1.1(cre)Slab/Grik4+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm2.1Kldr mutation (0 available); any Epha4 mutation (67 available)
Epha4tm2Kldr mutation (0 available); any Epha4 mutation (67 available)
Grik4tm1.1(cre)Slab mutation (2 available); any Grik4 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:154648 )
N
• mice exhibit normal long term potentiation and excitatory postsynaptic potential to theta burst- and tetanus-induced stimulation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory