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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Epha4tm2.1Kldr
targeted mutation 2.1, Klas Kullander
MGI:4398687
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Epha4tm2.1Kldr/Epha4tm2.1Kldr involves: BALB/c * C57BL/6 MGI:4398697
cn2
 		Epha4tm2Kldr/Epha4tm2.1Kldr
Grik4tm1.1(cre)Slab/Grik4+ 		involves: C57BL/6 MGI:4398696


Genotype
MGI:4398697
hm1
Allelic
Composition		 Epha4tm2.1Kldr/Epha4tm2.1Kldr
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm2.1Kldr mutation (0 available); any Epha4 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal miniature excitatory postsynaptic currents ( J:154648 )
• gamma-D-glutamylglycine treatment of hippocampal slices reduces the amplitude of miniature excitatory postsynaptic currents more than in similarly treated wild-type tissues




Genotype
MGI:4398696
cn2
Allelic
Composition		 Epha4tm2Kldr/Epha4tm2.1Kldr
Grik4tm1.1(cre)Slab/Grik4+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm2.1Kldr mutation (0 available); any Epha4 mutation (67 available)
Epha4tm2Kldr mutation (0 available); any Epha4 mutation (67 available)
Grik4tm1.1(cre)Slab mutation (2 available); any Grik4 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:154648 )
N
• mice exhibit normal long term potentiation and excitatory postsynaptic potential to theta burst- and tetanus-induced stimulation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory