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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(GFAP-EFNA3)181Kln
transgene insertion 181, Rudiger Klein
MGI:4398695
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(GFAP-EFNA3)181Kln/0 involves: C57BL/6 * FVB MGI:4398700


Genotype
MGI:4398700
tg1
Allelic
Composition		 Tg(GFAP-EFNA3)181Kln/0
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
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♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased susceptibility to pharmacologically induced seizures ( J:154648 )
• PTZ-treated mice exhibit increased seizure severity and more whole-body myocloni compared with similarly treated wild-type mice
abnormal dendrite morphology ( J:154648 )
• CA1 neurons exhibit dendritic beading and spine loss indicative of glutamate excitotoxicity unlike wild-type dendrites

behavior/neurological
increased susceptibility to pharmacologically induced seizures ( J:154648 )
• PTZ-treated mice exhibit increased seizure severity and more whole-body myocloni compared with similarly treated wild-type mice




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory