About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(GFAP-EFNA3)181Kln
transgene insertion 181, Rudiger Klein
MGI:4398695
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(GFAP-EFNA3)181Kln/0 involves: C57BL/6 * FVB MGI:4398700


Genotype
MGI:4398700
tg1
Allelic
Composition		 Tg(GFAP-EFNA3)181Kln/0
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased susceptibility to pharmacologically induced seizures ( J:154648 )
• PTZ-treated mice exhibit increased seizure severity and more whole-body myocloni compared with similarly treated wild-type mice
abnormal dendrite morphology ( J:154648 )
• CA1 neurons exhibit dendritic beading and spine loss indicative of glutamate excitotoxicity unlike wild-type dendrites

behavior/neurological
increased susceptibility to pharmacologically induced seizures ( J:154648 )
• PTZ-treated mice exhibit increased seizure severity and more whole-body myocloni compared with similarly treated wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory