Phenotypes associated with this allele

• Allele Symbol: Skil^tm1.1Kluo
• Allele Name: targeted mutation 1, Kunxin Luo
• Allele ID: MGI:4398740
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Skil^tm1.1Kluo/Skil^tm1.1Kluo	B6.129P2-Skil^tm1.1Kluo	MGI:4398827

Genotype
MGI:4398827

hm1

• Allelic Composition: Skil^tm1.1Kluo/Skil^tm1.1Kluo
• Genetic Background: B6.129P2-Skil^tm1.1Kluo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:154718 )

• 37% of mice die prior to birth

• however, surviving mice live up to 24 months

neoplasm

decreased incidence of tumors by chemical induction ( J:154718 )

• 40% of mice treated with TPA and DMBA develop tumors compared with 80% of similarly treated wild-type mice

• fewer tumors form in mice treated with TPA and DMBA than in similarly treated wild-type mice

decreased tumor growth/size ( J:154718 )

• after a short period tumors in TPA/DMBA-treated mice cease growing and spontaneously regress unlike in similarly treated wild-type mice

cellular

decreased fibroblast proliferation ( J:154718 )

• mouse embryonic fibroblasts treated with TGF-beta exhibit reduced growth compared with similarly treated wild-type cells

early cellular replicative senescence ( J:154718 )

• in a 3T9 protocol, 80% of mouse embryonic fibroblasts enter senescence prematurely compared with wild-type cells

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:154718 )

• 40% of mice treated with TPA and DMBA develop tumors compared with 80% of similarly treated wild-type mice

• fewer tumors form in mice treated with TPA and DMBA than in similarly treated wild-type mice