Phenotypes associated with this allele

• Allele Symbol: Vps53^tm1Xtz
• Allele Name: targeted mutation 1, XT Zhao
• Allele ID: MGI:4398894
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vps53^tm1Xtz/Vps53^tm1Xtz	involves: 129S1/Sv * C57BL/6J	MGI:4398895

Genotype
MGI:4398895

hm1

• Allelic Composition: Vps53^tm1Xtz/Vps53^tm1Xtz
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:154272 )

• mice die prior to E12.5

embryo

embryonic growth retardation ( J:154272 )

• beginning at E7.5

decreased embryo size ( J:154272 )

• beginning at E7.5

increased trophoblast giant cell number ( J:154272 )

• proliferation of trophoblasts is increased compared to in wild-type mice

abnormal placenta labyrinth morphology ( J:154272 )

• at E9.5, the placenta labyrinth accumulates large clusters of densely packed tropholast cells unlike in wild-type mice

• trophoblast transport surface area is reduced compared to in wild-type mice

• proliferation of trophoblasts is increased compared to in wild-type mice

growth/size/body

embryonic growth retardation ( J:154272 )

• beginning at E7.5

decreased embryo size ( J:154272 )

• beginning at E7.5