All Phenotypes Gt(ROSA)26Sor<tm1(CAG-Bmi1,-EGFP)Nki> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}
targeted mutation 1, The Netherlands Cancer Institute
MGI:4398910

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Rb1^tm2Brn/Rb1^tm2Brn Tg(Gfap-cre)2Brn/0	either: (involves: 129 * 129P2/OlaHsd * FVB/N) or (involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N)	MGI:5437516
cn2	Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Rb1^tm2Brn/Rb1^tm2Brn Trp53^tm1Brn/Trp53^tm1Brn Tg(Gfap-cre)2Brn/0	either: (involves: 129 * 129P2/OlaHsd * FVB/N) or (involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N)	MGI:5437517
cn3	Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Tg(Gfap-cre)2Brn/0	either: (involves: 129P2/OlaHsd * FVB/N) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)	MGI:5437515
cn4	Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Tg(Pbsn-cre)4Prb/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N	MGI:5427497
cn5	Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Pten^tm1Mro/Pten⁺ Tg(Pbsn-cre)4Prb/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N	MGI:5427498

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Rb1^tm2Brn/Rb1^tm2Brn Tg(Gfap-cre)2Brn/0
Genetic Background	either: (involves: 129 * 129P2/OlaHsd * FVB/N) or (involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki} mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
Rb1^tm2Brn mutation (3 available); any Rb1 mutation (111 available)
Tg(Gfap-cre)2Brn mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:187257 )

neoplasm

neoplasm ( J:187257 )

N	• mice do not develop medulloblastoma

increased pituitary gland tumor incidence ( J:187257 )

endocrine/exocrine glands

increased pituitary gland tumor incidence ( J:187257 )

nervous system

increased pituitary gland tumor incidence ( J:187257 )

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Rb1^tm2Brn/Rb1^tm2Brn Trp53^tm1Brn/Trp53^tm1Brn Tg(Gfap-cre)2Brn/0
Genetic Background	either: (involves: 129 * 129P2/OlaHsd * FVB/N) or (involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pituitary gland tumor incidence ( J:187257 )

increased medulloblastoma incidence ( J:187257 )

• as in Rb1^tm2Brn/Rb1^tm2Brn Trp53^tm1Brn/Trp53^tm1Brn Tg(Gfap-cre)2Brn mice

increased carcinoma incidence ( J:187257 )

• large cell carcinoma

endocrine/exocrine glands

increased pituitary gland tumor incidence ( J:187257 )

nervous system

increased pituitary gland tumor incidence ( J:187257 )

increased medulloblastoma incidence ( J:187257 )

• as in Rb1^tm2Brn/Rb1^tm2Brn Trp53^tm1Brn/Trp53^tm1Brn Tg(Gfap-cre)2Brn mice

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Tg(Gfap-cre)2Brn/0
Genetic Background	either: (involves: 129P2/OlaHsd * FVB/N) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Pituitary tumor in Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Tg(Gfap-cre)2Brn/0 mice

mortality/aging

premature death ( J:187257 )

neoplasm

increased tumor incidence ( J:187257 )

• pituitary tumors, mammary gland tumors and primitive neuroectodermal tumors

increased pituitary gland tumor incidence ( J:187257 )

• 8 of 16 solid tumors with a latency of a year

• intermediate and anterior lobe

• positive for adrenocorticotropic hormone

increased mammary gland tumor incidence ( J:187257 )

nervous system

increased pituitary gland tumor incidence ( J:187257 )

• 8 of 16 solid tumors with a latency of a year

• intermediate and anterior lobe

• positive for adrenocorticotropic hormone

endocrine/exocrine glands

increased pituitary gland tumor incidence ( J:187257 )

• 8 of 16 solid tumors with a latency of a year

• intermediate and anterior lobe

• positive for adrenocorticotropic hormone

increased mammary gland tumor incidence ( J:187257 )

integument

increased mammary gland tumor incidence ( J:187257 )

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Prostate cancer progression in Tg(Pbsn-cre)4Prb/0 Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺, Tg(Pbsn-cre)4Prb/0 Pten^tm1Mro/Pten⁺, and Tg(Pbsn-cre)4Prb/0 Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Pten^tm1Mro/Pten⁺ mice

reproductive system

prostate gland hyperplasia ( J:184533 )

• at 6 months, mice exhibit atypical hyperplastic foci in the prostate lobes unlike control mice

increased prostate intraepithelial neoplasia incidence ( J:184533 )

• multifocal lesions at 9 months

neoplasm

neoplasm ( J:184533 )

N	• mice do not develop adenocarcinomas

increased prostate intraepithelial neoplasia incidence ( J:184533 )

• multifocal lesions at 9 months

endocrine/exocrine glands

prostate gland hyperplasia ( J:184533 )

• at 6 months, mice exhibit atypical hyperplastic foci in the prostate lobes unlike control mice

increased prostate intraepithelial neoplasia incidence ( J:184533 )

• multifocal lesions at 9 months

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Pten^tm1Mro/Pten⁺ Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki} mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
Pten^tm1Mro mutation (1 available); any Pten mutation (88 available)
Tg(Pbsn-cre)4Prb mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate gland adenocarcinoma incidence ( J:184533 )

• 55% penetrance at 1 year

• multifocal, predominantly localized in the dorsolateral lobe that are locally invasive and highly vascularized

increased prostate intraepithelial neoplasia incidence ( J:184533 )

• at 6 months

renal/urinary system

urinary bladder obstruction ( J:184533 )

• frequently

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:184533 )

• 55% penetrance at 1 year

• multifocal, predominantly localized in the dorsolateral lobe that are locally invasive and highly vascularized

increased prostate intraepithelial neoplasia incidence ( J:184533 )

• at 6 months

reproductive system

increased prostate gland adenocarcinoma incidence ( J:184533 )

• 55% penetrance at 1 year

• multifocal, predominantly localized in the dorsolateral lobe that are locally invasive and highly vascularized

increased prostate intraepithelial neoplasia incidence ( J:184533 )

• at 6 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:184533

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