Phenotypes associated with this allele

• Allele Symbol: Steap3^tm1.1Atel
• Allele Name: targeted mutation 1.1, Adam Telerman
• Allele ID: MGI:4398911
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Steap3^tm1.1Atel/Steap3^tm1.1Atel	involves: C57BL/6	MGI:4398913

Genotype
MGI:4398913

hm1

• Allelic Composition: Steap3^tm1.1Atel/Steap3^tm1.1Atel
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased splenocyte apoptosis ( J:154356 )

• less TUNEL positive cells and PARP cleavage in the spleen after irraddiation

• decreased number of Annexin V-positive splenocytes after irradiation

abnormal vesicle-mediated transport ( J:154356 )

• the high-level transferring receptor (Tf-R) population in the bone marrow erythroblasts and the peripheral blood reticulocytes are significantly higher

• reticulocyte maturation assay by Phenylhydrazine showed retention of the Tf-R

• retention of the Tf-R and reduced secretion of exosomes in bone marrow-derived dendritic cells (BMDCs)

• reduced Tf-R content in purified exosomes from BMDCs

• reduced exosomal protein secretion (50%) in mouse embryo fibroblasts (MEFs) and bone marrow-derived dendritic cells (BMDCs) after DNA damage

hematopoietic system

decreased splenocyte apoptosis ( J:154356 )

• less TUNEL positive cells and PARP cleavage in the spleen after irraddiation

• decreased number of Annexin V-positive splenocytes after irradiation

abnormal erythropoiesis ( J:154356 )

extramedullary hematopoiesis ( J:154356 )

microcytic anemia ( J:154356 )

• decreased level of hemoglobin

increased erythroid progenitor cell number ( J:154356 )

• increased number of red blood cell precursors (erythroblasts) in the bone marrow

• the percentage of the transferring receptor (Tf-R)-labeled red cells in blood was higher (erythroid population, 3 fold)

increased erythrocyte cell number ( J:154356 )

• increased number of red blood cells in peripheral blood

decreased mean corpuscular hemoglobin ( J:154356 )

• decreased mean corpuscular hemoglobin (MCH)

decreased mean corpuscular volume ( J:154356 )

• decreased mean corpuscular volume (MCV)

anisopoikilocytosis ( J:154356 )

• smaller and abnormal shape erythrocytes

thrombocytosis ( J:154356 )

• increased platelets in peripheral blood

abnormal reticulocyte morphology ( J:154356 )

• smaller and abnormal shape reticulocytes

abnormal spleen morphology ( J:154356 )

increased spleen weight ( J:154356 )

• significant splenomegaly

abnormal spleen red pulp morphology ( J:154356 )

• the red pulp showing small cells irregular in shape and variable in size

increased spleen white pulp amount ( J:154356 )

• the white pulp being more spread

homeostasis/metabolism

abnormal blood osmolality ( J:154356 )

• pronounced osmotic fragility

increased circulating glucose level ( J:154356 )

• mild hyperglycemia in female mice

immune system

decreased splenocyte apoptosis ( J:154356 )

• less TUNEL positive cells and PARP cleavage in the spleen after irraddiation

• decreased number of Annexin V-positive splenocytes after irradiation

abnormal spleen morphology ( J:154356 )

increased spleen weight ( J:154356 )

• significant splenomegaly

abnormal spleen red pulp morphology ( J:154356 )

• the red pulp showing small cells irregular in shape and variable in size

increased spleen white pulp amount ( J:154356 )

• the white pulp being more spread

growth/size/body

increased spleen weight ( J:154356 )

• significant splenomegaly