All Phenotypes Timp3<tm1Osya> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Timp3^tm1Osya/Timp3^tm1Osya	B6.129P2-Timp3^tm1Osya	MGI:4399118
hm2	Timp3^tm1Osya/Timp3^tm1Osya	involves: 129P2/OlaHsd * C57BL/6	MGI:4399117
hm3	Timp3^tm1Osya/Timp3^tm1Osya	involves: 129P2/OlaHsd * C57BL/6J	MGI:5617484
cx4	Mmp2^tm1Ito/Mmp2^tm1Ito Timp3^tm1Osya/Timp3^tm1Osya	involves: 129P2/OlaHsd * C57BL/6	MGI:5516118

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal kidney morphology ( J:154849 )

• following unilateral ureter obstruction, mice exhibit increased kidney size, distended renal tissue, unclear border between the outer and inner medulla, severe hydronephrosis, and smaller medulla to cortex ratio compared with similarly treated wild-type mice

enlarged kidney ( J:154849 )

• following unilateral ureter obstruction compared with similarly treated wild-type mice

hydronephrosis ( J:154849 )

• more severe following unilateral ureter obstruction compared to in similarly treated wild-type mice

homeostasis/metabolism

increased susceptibility to injury ( J:154849 )

cardiovascular system

cardiovascular system phenotype ( J:154849 )

N	• mice exhibit normal blood pressure and heart rate

abnormal aorta morphology ( J:193744 )

• mutants exhibit adverse aortic remodeling after 2 weeks of angiotensin II infusion compared to wild-type mice, showing disorganized and disrupted elastin fibers and disorganized collagen structures, especially in the abdominal aorta

abnormal aorta wall morphology ( J:193744 )

• angiotensin II infused mutants exhibit disrupted medial elastic lamellae and fibrillar structures in the abdominal aortic walls

abnormal abdominal aorta morphology ( J:193744 )

• mutants treated with angiotensin II exhibit an increase in macrophage infiltration in the abdominal aorta and disrupted medial elastic lamellae and fibrillar structures in the abdominal aortic walls

abdominal aorta aneurysm ( J:193744 )

• 60% of mutants develop abdominal aortic aneurysm after 4 weeks of angiotensin II infusion unlike wild-type mice, showing greater than 50% aortic dilation in the suprarenal region

• treatment with a broad spectrum protease inhibitor, PD166793, during the course of angiotensin II infusion blocks abdominal aortic aneurysm development

abnormal blood vessel physiology ( J:193744 )

• the aortic systolic expansion index, a measure of aortic elasticity and recoil property during systole and diastole is suppressed in the aneurysmal aorta of angiotensin II infused mutants

aortitis ( J:193744 )

• mutants treated with angiotensin II exhibit an increase in macrophage infiltration in the abdominal aorta

immune system

aortitis ( J:193744 )

• mutants treated with angiotensin II exhibit an increase in macrophage infiltration in the abdominal aorta

mortality/aging

premature death ( J:193744 )

• survival is compromised after angiotensin II infusion due to aortic rupture, with mice showing 80-85% survival 28 days after infusion

growth/size/body

enlarged kidney ( J:154849 )

• following unilateral ureter obstruction compared with similarly treated wild-type mice

Allelic Composition	Timp3^tm1Osya/Timp3^tm1Osya
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Timp3^tm1Osya mutation (0 available); any Timp3 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:154709 )

N	• mice exhibit normal passive avoidance and active avoidance

abnormal learning/memory/conditioning ( J:154709 )

• after several days in an open-field, mice fail to become accustomed to their environment, as determined by maintenance of novel environment locomotion and rearing levels, unlike similarly treated wild-type mice

abnormal spatial learning ( J:154709 )

• in a water maze test with invisible platform, mice exhibit reduced memory acquisition on day 2 compared with wild-type mice

• deficit in memory acquisition in a water maze test with invisible platform lessens with time

• however, by day 5 memory acquisition in a water maze with invisible platform is normal and performance in a water maze test with visible platform is normal

cardiovascular system

cardiovascular system phenotype ( J:211441 )

N	• whether or not infused with angiotensin II, mice exhibit normal heart rate

abnormal artery morphology ( J:211441 )

• disorganized extracellular matrix collagen fibers with reduced collagen I protein level in the carotid arteries of mice treated with angiotensin II

• however, doxycycline treatment prevents aberrant arterial extracellular matrix degradation

abnormal blood vessel elastic tissue morphology ( J:211441 )

• disorganized and interrupted elastin fibers and lower elastin protein content in carotid arteries of mice treated with angiotensin II

abnormal systemic arterial blood pressure ( J:211441 )

• following angiotensin II infusion, mice fail to exhibit an increase in blood pressure as observed in wild-type mice

decreased systemic arterial blood pressure ( J:211441 )

• at baseline

abnormal blood vessel physiology ( J:211441 )

• following angiotensin II infusion, mesenteric arteries exhibit a reduced increase in media to lumen ratio with reduced medial thickness and increased lumen diameter compared with wild-type mice

• however, doxycycline treatment prevents reduction in media to lumen ratio

decreased vasodilation ( J:211441 )

• following angiotensin II infusion, arteries are more distensible than in wild-type mice

• however, doxycycline treatment prevents reduction lumen dilation

muscle

decreased vasodilation ( J:211441 )

• following angiotensin II infusion, arteries are more distensible than in wild-type mice

• however, doxycycline treatment prevents reduction lumen dilation

Allelic Composition	Timp3^tm1Osya/Timp3^tm1Osya
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Timp3^tm1Osya mutation (0 available); any Timp3 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased susceptibility to induced hypothermia ( J:215209 )

• mice exposed to a cold environment for 8 hours exhibit a higher core body temperature than wild-type mice, indicating enhanced adaptive thermogenesis

increased body temperature ( J:215209 )

• mice exhibit higher body temperature

• however food intake, locomotor activity, respiratory exchange ratio and body weight are normal

increased carbon dioxide production ( J:215209 )

• mice show higher carbon dioxide production at 15 weeks and 8 months of age

• mice show a greater increase in carbon dioxide production in response to treadmill-based exercise than wild-type mice

increased oxygen consumption ( J:215209 )

• mice show increased oxygen consumption at 15 weeks and 8 months of age

• mice show a greater increase in oxygen consumption in response to treadmill-based exercise than wild-type mice

Allelic Composition	Mmp2^tm1Ito/Mmp2^tm1Ito Timp3^tm1Osya/Timp3^tm1Osya
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp2^tm1Ito mutation (1 available); any Mmp2 mutation (25 available)
Timp3^tm1Osya mutation (0 available); any Timp3 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal aorta wall morphology ( J:193744 )

• angiotensin II infused mutants exhibit a greater disruption of the medial elastic lamellae and fibrillar structures in the abdominal aortic walls than in single Timp3 homozygotes

abnormal abdominal aorta morphology ( J:193744 )

• angiotensin II infused mutants exhibit a greater disruption of the medial elastic lamellae and fibrillar structures in the abdominal aortic walls than in single Timp3 homozygotes

increased susceptibility to induced aneurysm formation ( J:193744 )

• 75% of mutants develop abdominal aortic aneurysm with greater than 50% aortic dilation in the suprarenal region after 4 weeks of angiotensin II infusion

• survival is compromised more than in single Timp3 homozygotes after angiotensin II infusion due to aortic rupture, with mice showing around 70% survival 28 days after infusion

• treatment with a broad spectrum protease inhibitor, PD166793, during the course of angiotensin II infusion blocks abdominal aortic aneurysm development

aortitis ( J:193744 )

• mutants treated with angiotensin II exhibit heightened inflammation in the abdominal aorta, with enhanced infiltration of neutrophils and macrophages

immune system

aortitis ( J:193744 )

• mutants treated with angiotensin II exhibit heightened inflammation in the abdominal aorta, with enhanced infiltration of neutrophils and macrophages

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:193744 )

• survival is compromised more than in single Timp3 homozygotes after angiotensin II infusion due to aortic rupture, with mice showing around 70% survival 28 days after infusion

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