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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lhx2tm1.1Ddmo
targeted mutation 1.1, Dennis D M OLeary
MGI:4399043
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo
Neurod6tm1(cre)Kan/Neurod6+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:4399059
cn2
 		Emx1tm1(cre)Krj/Emx1+
Lhx2tm1.1Ddmo/Lhx2tm1.2Ddmo 		involves: 129S2/SvPas * C57BL/6 * SJL MGI:4399056
cn3
 		Emx1tm1(cre)Krj/Emx1+
Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo 		involves: 129S2/SvPas * C57BL/6 * SJL MGI:4399057
cn4
 		Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo
Tg(Nes-cre)1Kln/0 		involves: C57BL/6 * SJL MGI:4399058


Genotype
MGI:4399059
cn1
Allelic
Composition		 Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo
Neurod6tm1(cre)Kan/Neurod6+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx2tm1.1Ddmo mutation (0 available); any Lhx2 mutation (12 available)
Neurod6tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:154611 )
N
• mice exhibit normal development of the piriform cortex




Genotype
MGI:4399056
cn2
Allelic
Composition		 Emx1tm1(cre)Krj/Emx1+
Lhx2tm1.1Ddmo/Lhx2tm1.2Ddmo
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Lhx2tm1.1Ddmo mutation (0 available); any Lhx2 mutation (12 available)
Lhx2tm1.2Ddmo mutation (0 available); any Lhx2 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal telencephalon morphology ( J:154611 )
• the telencephalon exhibits abnormal patterning compared to in wild-type mice
abnormal neocortex morphology ( J:154611 )
• at P7, the cortices are half the size of the cortices in wild-type mice
• the neocortex is small with abnormal lamination patterns compared to in wild-type mice
• the lateral neocortex is replaced with an ectopic piriform cortex that is not a displaced endogenous piriform cortex but refated lateral neocortex cells
• the ectopic piriform cortex is 400% larger than the normal piriform cortex
• between E15.5 and P0 the endogenous piriform cortex disappears
• however, the neocortex is normal at E13.5
abnormal olfactory bulb morphology ( J:154611 )
• olfactory bulb projections continue beyond the ectopic piriform cortex and project into layer 1 through much of the neo cortex unlike in wild-type mice
abnormal olfactory cortex morphology ( J:154611 )
• the lateral neocortex is replaced with an ectopic piriform cortex that is not a displaced endogenous piriform cortex but refated lateral neocortex cells
• at P7, the piriform cortex is absent from its normal ventral position
• however, the piriform cortex is present at E13.5




Genotype
MGI:4399057
cn3
Allelic
Composition		 Emx1tm1(cre)Krj/Emx1+
Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Lhx2tm1.1Ddmo mutation (0 available); any Lhx2 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal telencephalon morphology ( J:154611 )
• the telencephalon exhibits abnormal patterning compared to in wild-type mice
abnormal neocortex morphology ( J:154611 )
• at P7, the cortices are half the size of the cortices in wild-type mice
• the neocortex is small with abnormal lamination patterns compared to in wild-type mice
• the lateral neocortex is replaced with an ectopic piriform cortex that is not a displaced endogenous piriform cortex but refated lateral neocortex cells
• the ectopic piriform cortex is 400% larger than the normal piriform cortex
• between E15.5 and P0 the endogenous piriform cortex disappears
• however, the neocortex is normal at E13.5
abnormal olfactory bulb morphology ( J:154611 )
• olfactory bulb projections continue beyond the ectopic piriform cortex and project into layer 1 through much of the neo cortex unlike in wild-type mice
abnormal olfactory cortex morphology ( J:154611 )
• the lateral neocortex is replaced with an ectopic piriform cortex that is not a displaced endogenous piriform cortex but refated lateral neocortex cells
• at P7, the piriform cortex is absent from its normal ventral position
• however, the piriform cortex is present at E13.5




Genotype
MGI:4399058
cn4
Allelic
Composition		 Lhx2tm1.1Ddmo/Lhx2tm1.1Ddmo
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx2tm1.1Ddmo mutation (0 available); any Lhx2 mutation (12 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neocortex morphology ( J:154611 )
• at P7, the cortices are half the size of the cortices in wild-type mice
• however, the piriform cortex and lateral cortex are positioned normally




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory