Analysis Tools
nervous system
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• the telencephalon exhibits abnormal patterning compared to in wild-type mice
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• at P7, the cortices are half the size of the cortices in wild-type mice
• the neocortex is small with abnormal lamination patterns compared to in wild-type mice
• the lateral neocortex is replaced with an ectopic piriform cortex that is not a displaced endogenous piriform cortex but refated lateral neocortex cells
• the ectopic piriform cortex is 400% larger than the normal piriform cortex
• between E15.5 and P0 the endogenous piriform cortex disappears
• however, the neocortex is normal at E13.5
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• olfactory bulb projections continue beyond the ectopic piriform cortex and project into layer 1 through much of the neo cortex unlike in wild-type mice
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• the lateral neocortex is replaced with an ectopic piriform cortex that is not a displaced endogenous piriform cortex but refated lateral neocortex cells
• at P7, the piriform cortex is absent from its normal ventral position
• however, the piriform cortex is present at E13.5
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