Phenotypes associated with this allele

• Allele Symbol: Gdf15^tm1Kuns
• Allele Name: targeted mutation 1, Klaus Unsicker
• Allele ID: MGI:4399064
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gdf15^tm1Kuns/Gdf15^tm1Kuns	involves: 129S2/SvPas * C57BL/6	MGI:4399095

Genotype
MGI:4399095

hm1

• Allelic Composition: Gdf15^tm1Kuns/Gdf15^tm1Kuns
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:154446 )

• increased body weight (16%) in adult female homozygous mice

nervous system

decreased neuron number ( J:154446 )

• a 13% loss in myelinated axons

• no difference in the number of superior cervical ganglia (SCG) sympathetic neurons

decreased motor neuron number ( J:154446 )

• no effect on the extent of programmed cell death (PCD) of lumbar spinal and selected brainstem motoneurons

• no detectable differences with respect to size, nuclear and cytoplasmic areas as well as Nissl morphology in the remaining motoneurons

• loss of trigeminal and facial motoneurons (19%), lumbar spinal motoneurons (21%) at the age of 6 monthsloss of trigeminal and facial motoneurons

abnormal somatic nervous system morphology ( J:154446 )

decreased sensory neuron number ( J:154446 )

• reduced neuron numbers in the dorsal root ganglia (DRG) L4 (22%) and L5 (25%) at 6 months

abnormal facial nerve morphology ( J:154446 )

• no difference in the numbers of facial motoneurons at P14 and 3 months of age

• 14% motoneuron loss in the facial nucleus at 4.5 months, which further increased at 6 months (19%), reaching a stable plateau thereafter until 12 months

abnormal trigeminal nerve morphology ( J:154446 )

• 19% cell loss of trigeminal motoneurons at the age of 6 months

abnormal L4 dorsal root ganglion morphology ( J:154446 )

• reduced neuron numbers in the dorsal root ganglia (DRG) L4 (22%) at 6 months

abnormal L5 dorsal root ganglion morphology ( J:154446 )

• reduced neuron numbers in the dorsal root ganglia (DRG) L5 (25%) at 6 months

behavior/neurological

impaired coordination ( J:154446 )

• significantly impaired ability to remain on an accelerating rotarod