Phenotypes associated with this allele

• Allele Symbol: Gcg^tm1Yhys
• Allele Name: targeted mutation 1, Yoshitaka Hayashi
• Allele ID: MGI:4399066
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gcg^tm1Yhys/Gcg^tm1Yhys	B6.129S6-Gcg^tm1Yhys	MGI:4399080

Genotype
MGI:4399080

hm1

• Allelic Composition: Gcg^tm1Yhys/Gcg^tm1Yhys
• Genetic Background: B6.129S6-Gcg^tm1Yhys

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:154694 )

• 10% of mice fail to grow and are lost by 4 weeks of age

homeostasis/metabolism

increased circulating glucose level ( J:154694 )

• at 2 weeks but not at 2 to 3 months when fed at libitum

decreased circulating insulin level ( J:154694 )

• when fed at libitum but not after 16 hour starvation

improved glucose tolerance ( J:154694 )

• more prominent in female mice than in males

increased insulin sensitivity ( J:154694 )

• more prominent in female mice than in males

digestive/alimentary system

digestive/alimentary phenotype ( J:154694 )

N • intestinal L cells are normal

growth/size/body

increased pancreas weight ( J:154694 )

• 2-fold

increased body weight ( J:154694 )

• at 2 months, female and male mice weight 20% and 10% more than wild-type mice, respectively

• increased body weight is more prominent in female mice than in males

• however, body mass index is unchanged

increased body length ( J:154694 )

postnatal growth retardation ( J:154694 )

• 10% of mice fail to grow and are lost by 4 weeks of age

renal/urinary system

polyuria ( J:154694 )

• in female mice

endocrine/exocrine glands

abnormal pancreatic alpha cell morphology ( J:154694 )

• mice develop alpha cell hyperplasia by P3

increased pancreatic islet number ( J:154694 )

increased pancreas weight ( J:154694 )

• 2-fold