Phenotypes associated with this allele

• Allele Symbol: Gpr183^tm1.1Cys
• Allele Name: targeted mutation 1.1, Jason G Cyster
• Allele ID: MGI:4399081
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpr183^tm1.1Cys/Gpr183^tm1.1Cys	B6.129P2-Gpr183^tm1.1Cys	MGI:4399082

Genotype
MGI:4399082

hm1

• Allelic Composition: Gpr183^tm1.1Cys/Gpr183^tm1.1Cys
• Genetic Background: B6.129P2-Gpr183^tm1.1Cys

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal follicular B cell physiology ( J:151077 )

• in an adoptive transfer experiments, activated B cells fail to migrate from site of transfer and instead favor the central follicle unlike similarly treated wild-type cells

• however, activated B cell follicle localization is indistinguishable from that of wild-type cells in adoptive transfer experiments into Cxcl13^tm1Cys homozygotes

hematopoietic system

abnormal follicular B cell physiology ( J:151077 )

• in an adoptive transfer experiments, activated B cells fail to migrate from site of transfer and instead favor the central follicle unlike similarly treated wild-type cells

• however, activated B cell follicle localization is indistinguishable from that of wild-type cells in adoptive transfer experiments into Cxcl13^tm1Cys homozygotes