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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wnt4tm1.1Svo
targeted mutation 1.1, Seppo Vainio
MGI:4399114
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Wnt4tm1.1Svo/Wnt4tm1.1Svo involves: 129/Sv * C57BL/6 MGI:4399124
cn2
 		Wnt4tm1.1Svo/Wnt4tm1.1Svo
Tg(CAG-cre)13Miya/0 		involves: 129/Sv * C57BL/6 MGI:4399125


Genotype
MGI:4399124
hm1
Allelic
Composition		 Wnt4tm1.1Svo/Wnt4tm1.1Svo
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt4tm1.1Svo mutation (1 available); any Wnt4 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:154784 )
• mice exhibit none of the phenotypes observed in heterozygous Wnt4 null mice




Genotype
MGI:4399125
cn2
Allelic
Composition		 Wnt4tm1.1Svo/Wnt4tm1.1Svo
Tg(CAG-cre)13Miya/0
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cre)13Miya mutation (1 available)
Wnt4tm1.1Svo mutation (1 available); any Wnt4 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Impaired kidney development in Wnt4tm1.1Svo/Wnt4tm1.1Svo Tg(CAG-cre)13Miya/0 fetuses

renal/urinary system
abnormal kidney development ( J:154784 )
• kidney development is impaired and the kidneys remain rudimentary




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory