All Phenotypes Wnt4<tm2(EGFP/cre)Svo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Wnt4^{tm2(EGFP/cre)Svo}
targeted mutation 2, Seppo Vainio
MGI:4399121

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Wnt4^{tm2(EGFP/cre)Svo}/Wnt4^tm1Svo	involves: 129/Sv * C57BL/6	MGI:4399126
cn2	Hnf1b^tm1Ics/Hnf1b⁺ Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺	involves: 129P2/OlaHsd	MGI:5471841
cn3	Hnf1b^tm1Sce/Hnf1b⁺ Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺	involves: 129P2/OlaHsd	MGI:5471842
cn4	Hnf1b^tm1Ics/Hnf1b^tm1Sce Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺	involves: 129P2/OlaHsd	MGI:5471840
cn5	Dkk1^tm1.1Svo/Dkk1^tm1.2Svo Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5013425
cn6	Tcf21^tm2.1Seq/Tcf21^tm1Jrt Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5613386

Allelic Composition	Wnt4^{tm2(EGFP/cre)Svo}/Wnt4^tm1Svo
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt4^tm1Svo mutation (0 available); any Wnt4 mutation (21 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Severe anomalies in the urogenital system in Wnt4^{tm2(EGFP/cre)Svo}/Wnt4^tm1Svo mice

renal/urinary system

abnormal kidney development ( J:154784 )

• some mice exhibit occasional glomerula and nephron structures

abnormal kidney mesenchyme morphology ( J:154784 )

• mesenchyme in the developing kidney remains undifferentiated compared to in wild-type mice

small kidney ( J:154784 )

• at E18.5

absent kidney ( J:154784 )

reproductive system

absent ovary capsule ( J:154784 )

• ovaries remain are not encapsulated

abnormal ovary development ( J:154784 )

• ovaries remain round and are not encapsulated unlike in wild-type mice

primary sex reversal ( J:154784 )

• female mice exhibit partial sex reversal with persistent Wolffian duct and failure of Mullerian duct development unlike in wild-type mice

endocrine/exocrine glands

absent ovary capsule ( J:154784 )

• ovaries remain are not encapsulated

abnormal ovary development ( J:154784 )

• ovaries remain round and are not encapsulated unlike in wild-type mice

Allelic Composition	Hnf1b^tm1Ics/Hnf1b⁺ Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf1b^tm1Ics mutation (0 available); any Hnf1b mutation (16 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal glomerulus cyst ( J:194051 )

• in some mice

abnormal renal tubule morphology ( J:194051 )

• enlarged, more obvious at E15.5 than at P0

growth/size/body

renal glomerulus cyst ( J:194051 )

• in some mice

Allelic Composition	Hnf1b^tm1Sce/Hnf1b⁺ Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf1b^tm1Sce mutation (2 available); any Hnf1b mutation (16 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:194051 )

N	• glomerular cysts and enlarged tubules are not seen, unlike in mice heterozygous for Hnf1b^tm1Ics and Wnt4^{tm2(EGFP/cre)Svo}

Allelic Composition	Hnf1b^tm1Ics/Hnf1b^tm1Sce Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf1b^tm1Ics mutation (0 available); any Hnf1b mutation (16 available)
Hnf1b^tm1Sce mutation (2 available); any Hnf1b mutation (16 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:194051 )

• die within the first 2 days after birth

renal/urinary system

abnormal kidney morphology ( J:194051 )

• higher density of mature glomeruli in the medulla region compared to the periphery unlike in controls

renal glomerulus cyst ( J:194051 )

• 12-16% of glomeruli become cystic

abnormal metanephros morphology ( J:194051 )

• expression analysis indicates a defect in proximal and intermediate regions of the S-shaped bodies development during tubule development

• S-shaped bodies appear less convoluted

• decrease in proliferation in comma-shaped bodies and a stronger decrease in the future proximal tubule of S-shaped bodies at E16.5

• increase in apoptosis in kidney epithelium but not stroma at E16.5

• strong increase in apoptosis in late mutant nephron tubules and a more moderate increase in S-shaped bodies

hydronephrosis ( J:194051 )

• occasional

abnormal renal tubule morphology ( J:194051 )

• decrease in tubular structures

• reduction of 43.5% in mature glomeruli mutant kidneys

• higher density of mature glomeruli in the medulla region compared to the periphery unlike in controls

abnormal loop of Henle morphology ( J:194051 )

• medullar elongated loop of Henle tubules are not visible at P0

abnormal proximal convoluted tubule morphology ( J:194051 )

• not visible at P0

growth/size/body

renal glomerulus cyst ( J:194051 )

• 12-16% of glomeruli become cystic

Allelic Composition	Dkk1^tm1.1Svo/Dkk1^tm1.2Svo Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1^tm1.1Svo mutation (1 available); any Dkk1 mutation (18 available)
Dkk1^tm1.2Svo mutation (0 available); any Dkk1 mutation (18 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:173125 )

N	• mice exhibit normal kidneys

Allelic Composition	Tcf21^tm2.1Seq/Tcf21^tm1Jrt Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf21^tm1Jrt mutation (0 available); any Tcf21 mutation (16 available)
Tcf21^tm2.1Seq mutation (0 available); any Tcf21 mutation (16 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal podocyte morphology ( J:217144 )

• defective foot process formation

• podocytes remain columnar at E18.5

abnormal renal glomerulus morphology ( J:217144 )

• glomeruli are primitive and reduced in size at E18.5

• complexity of glomerulus is reduced

small kidney ( J:217144 )

• slightly reduced in size but no overt abnormality in tubular formation

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