Phenotypes associated with this allele

• Allele Symbol: Wnt4^tm1Svo
• Allele Name: targeted mutation 1, Seppo Vainio
• Allele ID: MGI:4399122
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Wnt4^tm2(EGFP/cre)Svo/Wnt4^tm1Svo	involves: 129/Sv * C57BL/6	MGI:4399126

Genotype
MGI:4399126

cn1

• Allelic Composition: Wnt4^{tm2(EGFP/cre)Svo}/Wnt4^tm1Svo
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Severe anomalies in the urogenital system in Wnt4^{tm2(EGFP/cre)Svo}/Wnt4^tm1Svo mice

renal/urinary system

abnormal kidney development ( J:154784 )

• some mice exhibit occasional glomerula and nephron structures

abnormal kidney mesenchyme morphology ( J:154784 )

• mesenchyme in the developing kidney remains undifferentiated compared to in wild-type mice

small kidney ( J:154784 )

• at E18.5

absent kidney ( J:154784 )

reproductive system

absent ovary capsule ( J:154784 )

• ovaries remain are not encapsulated

abnormal ovary development ( J:154784 )

• ovaries remain round and are not encapsulated unlike in wild-type mice

primary sex reversal ( J:154784 )

• female mice exhibit partial sex reversal with persistent Wolffian duct and failure of Mullerian duct development unlike in wild-type mice

endocrine/exocrine glands

absent ovary capsule ( J:154784 )

• ovaries remain are not encapsulated

abnormal ovary development ( J:154784 )

• ovaries remain round and are not encapsulated unlike in wild-type mice