Phenotypes associated with this allele

• Allele Symbol: Tcf3^{tm6(Esr1*)Zhu}
• Allele Name: targeted mutation 6, Yuan Zhuang
• Allele ID: MGI:4399144
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcf3^tm6(Esr1*)Zhu/Tcf3^tm6(Esr1*)Zhu	involves: 129/Sv * C57BL/6	MGI:4399147

Genotype
MGI:4399147

hm1

• Allelic Composition: Tcf3^{tm6(Esr1*)Zhu}/Tcf3^{tm6(Esr1*)Zhu}
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:154788 )

• mice exhibit reduced survival

immune system

abnormal immunoglobulin heavy chain V(D)J recombination ( J:154788 )

• B cells fail to exhibit immunoglobulin heavy chain V(D)J rearrangement unlike wild-type cells

• however, in vitro treatment with tamoxifen restores immunoglobulin heavy chain V(D)J rearrangement

arrested B cell differentiation ( J:154788 )

• B cell development is blocked at the pre-pro B cell stage with some leaky B cell development that does not produce mature B cells

• tamoxifen treated mice do not exhibit restored robust B cell development

• however, in vitro treatment with tamoxifen promotes some B cell development beyond the pre-pro B cell stage

growth/size/body

postnatal growth retardation ( J:154788 )

• mice exhibit stunted growth

hematopoietic system

abnormal immunoglobulin heavy chain V(D)J recombination ( J:154788 )

• B cells fail to exhibit immunoglobulin heavy chain V(D)J rearrangement unlike wild-type cells

• however, in vitro treatment with tamoxifen restores immunoglobulin heavy chain V(D)J rearrangement

arrested B cell differentiation ( J:154788 )

• B cell development is blocked at the pre-pro B cell stage with some leaky B cell development that does not produce mature B cells

• tamoxifen treated mice do not exhibit restored robust B cell development

• however, in vitro treatment with tamoxifen promotes some B cell development beyond the pre-pro B cell stage