Phenotypes associated with this allele

• Allele Symbol: Ces2a^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:4399394
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ces2a^tm1(KOMP)Vlcg/Ces2a^tm1(KOMP)Vlcg	C57BL6/N-Ces2a^tm1(KOMP)Vlcg	MGI:7713397

Genotype
MGI:7713397

hm1

• Allelic Composition: Ces2a^{tm1(KOMP)Vlcg}/Ces2a^{tm1(KOMP)Vlcg}
• Genetic Background: C57BL6/N-Ces2a^{tm1(KOMP)Vlcg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body fat mass ( J:335459 )

• mice show increased fat mass when fed a chow or high-fat diet

• however, lean mass is normal and no differences in total energy expenditure, respiratory exchange ratio, locomotor activity, food intake, plasma fatty acid, glycerol, or ketone body levels

increased body weight ( J:335459 )

• mice show increased body weight when fed chow or high-fat diet (HFD)

increased liver weight ( J:335459 )

• liver weight is increased 1.7-fold when fed a HFD

adipose tissue

abnormal adipose tissue distribution ( J:335459 )

• mice show differences in regional fat distribution of white adipose tissue depots including increased perigonadal adipose tissue mass on chow diet but decreased perigonadal adipose tissue weight on HFD

increased body fat mass ( J:335459 )

• mice show increased fat mass when fed a chow or high-fat diet

• however, lean mass is normal and no differences in total energy expenditure, respiratory exchange ratio, locomotor activity, food intake, plasma fatty acid, glycerol, or ketone body levels

increased brown adipose tissue mass ( J:335459 )

• mice exhibit increased brown adipose tissue mass when fed chow or HFD

homeostasis/metabolism

increased circulating insulin level ( J:335459 )

• plasma insulin levels are elevated in HFD-fed mice in the fed state

decreased circulating triglyceride level ( J:335459 )

• mice show reduced plasma triacylglycerol levels when fasted and refed the HFD

increased circulating alanine transaminase level ( J:335459 )

• HFD-fed mice show increased alanine transaminase levels

increased circulating aspartate transaminase level ( J:335459 )

• HFD-fed mice show increased aspartate transaminase levels

impaired glucose tolerance ( J:335459 )

• glucose clearance following a glucose bolus declines in young and middle-aged HFD-fed mice, indicating glucose intolerance

insulin resistance ( J:335459 )

• plasma insulin levels are elevated in HFD-fed mice in the fed state, while blood glucose levels are unchanged in HFD-fed mice irrespective of feeding studies, indicating reduced insulin sensitivity

increased cholesterol level ( J:335459 )

• mice show increased cholesterol levels when fed chow or high fat diet

increased liver cholesterol level ( J:335459 )

• HFD-fed mice exhibit increased hepatic total cholesterol content

increased ceramide level ( J:335459 )

• total ceramide levels tend to be increased in the liver of HFD-fed mice

increased liver triglyceride level ( J:335459 )

• HFD-fed mice exhibit increased hepatic acylglycerol

immune system

liver inflammation ( J:335459 )

• HFD-fed mice show increased expression of genes involved in inflammation in the liver

liver/biliary system

increased liver weight ( J:335459 )

• liver weight is increased 1.7-fold when fed a HFD

increased liver cholesterol level ( J:335459 )

• HFD-fed mice exhibit increased hepatic total cholesterol content

increased liver triglyceride level ( J:335459 )

• HFD-fed mice exhibit increased hepatic acylglycerol

liver inflammation ( J:335459 )

• HFD-fed mice show increased expression of genes involved in inflammation in the liver

increased susceptibility to diet-induced hepatic steatosis ( J:335459 )

• HFD-fed mice show lipid accumulation in the liver, showing the presence of enlarged hepatic lipid droplets indicating aggravated diet-induced hepatic steatosis

• liver of HFD-fed mice shows 1.7-fold increase in total triacylglycerol (TAG), 2.6-fold increase in diacylglycerol (DAG) levels, and reduced monoacylglycerol (MAG) levels

• all DAG species measured are increased while only a couple of TAG species are increased in the liver

• HFD-fed mice accumulate predominately sn-1,2 (2,3) DAGs in liver tissue

liver fibrosis ( J:335459 )

• HFD-fed mice show increased expression of genes involved in fibrosis in the liver