Phenotypes associated with this allele

• Allele Symbol: Il18bp^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:4399404
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il18bp^tm1(KOMP)Vlcg/Il18bp^tm1(KOMP)Vlcg	C57BL/6-Il18bp^tm1(KOMP)Vlcg	MGI:6156428

Genotype
MGI:6156428

hm1

• Allelic Composition: Il18bp^{tm1(KOMP)Vlcg}/Il18bp^{tm1(KOMP)Vlcg}
• Genetic Background: C57BL/6-Il18bp^{tm1(KOMP)Vlcg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal NK cell differentiation ( J:255309 )

• increased number of Cd27+ Cd11b- cells in spleen and bone marrow

• reduced number of Cd27- Cd11b+ cells in spleen and bone marrow

• increased Tnfa expression in splenocytes in vitro after stimulation with Il18, Il18 + Il2, or lipopolysaccharide and subsequent treatment with PMA and ionomycin

• decreased Ifng expression in splenocytes in vitro after stimulation with Il18, Il18 + Il2, or lipopolysaccharide and subsequent treatment with PMA and ionomycin

• number of Cd27+ Cd11b+ and Cd27- Cd11b- cells in spleen

increased immature NK cell number ( J:255309 )

• increased number of Cd27+ Cd11b- cells in spleen and bone marrow

decreased NK cell number ( J:255309 )

• in spleen

decreased KLRG1-positive NK cell number ( J:255309 )

• in spleen

decreased mature NK cell number ( J:255309 )

• reduced number of Cd27- Cd11b+ cells in spleen and bone marrow

increased circulating interferon-gamma level ( J:255309 )

• after stimulation with lipopolysaccharide

decreased interferon-gamma secretion ( J:255309 )

• decreased Ifng expression in splenocytes in vitro after stimulation with Il18, Il18 + Il2, or lipopolysaccharide and subsequent treatment with PMA and ionomycin

hematopoietic system

abnormal NK cell differentiation ( J:255309 )

• increased number of Cd27+ Cd11b- cells in spleen and bone marrow

• reduced number of Cd27- Cd11b+ cells in spleen and bone marrow

• increased Tnfa expression in splenocytes in vitro after stimulation with Il18, Il18 + Il2, or lipopolysaccharide and subsequent treatment with PMA and ionomycin

• decreased Ifng expression in splenocytes in vitro after stimulation with Il18, Il18 + Il2, or lipopolysaccharide and subsequent treatment with PMA and ionomycin

• number of Cd27+ Cd11b+ and Cd27- Cd11b- cells in spleen

increased immature NK cell number ( J:255309 )

• increased number of Cd27+ Cd11b- cells in spleen and bone marrow

decreased NK cell number ( J:255309 )

• in spleen

decreased KLRG1-positive NK cell number ( J:255309 )

• in spleen

decreased mature NK cell number ( J:255309 )

• reduced number of Cd27- Cd11b+ cells in spleen and bone marrow

homeostasis/metabolism

increased circulating interferon-gamma level ( J:255309 )

• after stimulation with lipopolysaccharide

growth/size/body

growth/size/body region phenotype ( J:255309 )

N • weight gain during first 24 weeks