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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
B4gat1tm1(KOMP)Vlcg
targeted mutation 1, Velocigene
MGI:4399423
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
B4gat1tm1(KOMP)Vlcg/B4gat1tm1(KOMP)Vlcg involves: C57BL/6NTac MGI:5471463
ht2
B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg involves: C3H/He * C57BL/6 * C57BL/6NTac MGI:5471464


Genotype
MGI:5471463
hm1
Allelic
Composition
B4gat1tm1(KOMP)Vlcg/B4gat1tm1(KOMP)Vlcg
Genetic
Background
involves: C57BL/6NTac
Cell Lines 12887A-G3
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B4gat1tm1(KOMP)Vlcg mutation (1 available); any B4gat1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5471464
ht2
Allelic
Composition
B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic
Background
involves: C3H/He * C57BL/6 * C57BL/6NTac
Cell Lines 12887A-G3
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B4gat1m1Ddg mutation (1 available); any B4gat1 mutation (18 available)
B4gat1tm1(KOMP)Vlcg mutation (1 available); any B4gat1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die perinatally

nervous system
• mice exhibit axon defasciculation in the descending hindbrain projections compared with control mice
• mice exhibit axon defasciculation in the descending hindbrain projections compared with control mice
• endfoot detachment
• in the cerebellum and hippocampus
• at E11.5, commissural axons exhibit robust postcrossing trajectory defects with failure to project to the altered portion of the funiculus and altered lateral and ventral funiculi ratio compared with wild-type mice
• at E13, a large number of commissural axon project abnormally within the floor plate unlike in wild-type mice
• at E13.5, mice exhibit extensive disruptions in more lateral aspect of the ventrolateral funiculus compared with wild-type mice
• neuronal heterotopias
• mice exhibit axon defasciculation in the descending hindbrain projections compared with control mice

muscle
• in surviving mice

behavior/neurological

cellular
• mice exhibit axon defasciculation in the descending hindbrain projections compared with control mice
• mice exhibit axon defasciculation in the descending hindbrain projections compared with control mice
• endfoot detachment
• in the cerebellum and hippocampus
• at E11.5, mice exhibit progressive fragmentation of the basement membrane surrounding the spinal cord which is accompanied by detachment of radial neuroepithelial endfeet from the basal surface unlike wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
muscular dystrophy-dystroglycanopathy type B1 DOID:0050588 OMIM:613155
J:194150





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory