Phenotypes associated with this allele

• Allele Symbol: Tmprss2^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:4399580
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmprss2^tm1(KOMP)Vlcg/Tmprss2^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:5705124
cx2	Tg(DPP4)2Nnag/0 Tmprss2^tm1(KOMP)Vlcg/Tmprss2^tm1(KOMP)Vlcg	involves: C57BL/6NCr * C57BL/6NTac * DBA	MGI:6403636

Genotype
MGI:5705124

hm1

• Allelic Composition: Tmprss2^{tm1(KOMP)Vlcg}/Tmprss2^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytokine secretion ( J:283077 )

• mice inoculated intranasally with poly(I:C) show decreased cytokine levels in the lungs, including MCP-1/CCL2, KC/CXCL1, IL-1alpha, IL-5, IFN-gamma, and IL-17, indicating weaker or delayed inflammatory chemokine or cytokine responses

• SARS-CoV F-musX-infected mice show decreased levels of chemokines and cytokines in the lungs, with decreased concentrations of FGF-basic, keratinocyte-derived chemokine/CXCL1, IL-12, IL-4, and IL-10

lung inflammation ( J:214427 )

• reduced lung inflammation in all mice infected with H1N1, H3N2, or H7N9 strains of IAV (influenza type A virus)

• almost complete elimination of H1N1 and H3N2 virus by 6 days post infection

• no protection against H5N1 substrain of IAV, similar to controls

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:214427 )

• intranasal infection with up to 10⁵ PFU of H1N1 IAV fails to cause clinical signs or body weight loss in contrast to controls which died or required euthanasia

• H3N2 subtype results are similar to H1N1 except that moderate body weight loss is observed but complete recovery occurs

• disease susceptibility to H5N1 is similar to controls

decreased susceptibility to Coronaviridae infection ( J:283077 )

• mice show decreased susceptibility to infection with a mouse-adapted severe acute respiratory syndrome coronavirus (SARS-CoV) F-musX , with mice showing no body weight loss, lower viral replication in the lungs, milder lung pathology with decreased inflammatory infiltration and formation of granulation tissue in healing alveolar areas and decreased immune responses

respiratory system

lung inflammation ( J:214427 )

• reduced lung inflammation in all mice infected with H1N1, H3N2, or H7N9 strains of IAV (influenza type A virus)

• almost complete elimination of H1N1 and H3N2 virus by 6 days post infection

• no protection against H5N1 substrain of IAV, similar to controls

mortality/aging

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:214427 )

• intranasal infection with up to 10⁵ PFU of H1N1 IAV fails to cause clinical signs or body weight loss in contrast to controls which died or required euthanasia

• H3N2 subtype results are similar to H1N1 except that moderate body weight loss is observed but complete recovery occurs

• disease susceptibility to H5N1 is similar to controls

reproductive system

reproductive system phenotype ( J:214427 )

N • reproduction is normal

embryo

embryo phenotype ( J:214427 )

N • development is normal

growth/size/body

growth/size/body region phenotype ( J:214427 )

N • growth is normal

Genotype
MGI:6403636

cx2

• Allelic Composition: Tg(DPP4)2Nnag/0; Tmprss2^{tm1(KOMP)Vlcg}/Tmprss2^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NCr * C57BL/6NTac * DBA

immune system

abnormal cytokine secretion ( J:283077 )

• MERS-CoV-infected mice show a delay in and less pronounced chemokine and cytokine responses, with decreased concentrations of FGF-basic, GM-CSF, MIG/CXCL9, and TNF-alpha but increased levels of IL-6 and other inflammatory cytokines like MIP-1alpha, IL-1alpha and IL-1beta

decreased susceptibility to Coronaviridae infection ( J:283077 )

• mice show decreased susceptibility to infection with the EMC2012 strain of the Middle East respiratory syndrome coronavirus (MERS-CoV) , with no or only a slight weight loss, slower viral replication in the lungs, lower titers of neutralizing antibodies in sera, and less severe lung pathology with only mild mononuclear cell infiltration of the alveoli by 7 days post infection compared to single Tg(DPP4)2Nnag mice