Analysis Tools
mortality/aging
|
• the majority of mice die around 3 weeks of age with a few surviving into adulthood
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nervous system
| N |
• despite loss of mature oligodendrocytes, mice exhibit no abnormal neuronal cell death or axonal loss
|
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• oligodendrocytes are deficient in myelination compared to in wild-type mice
• oligodendrocyte maturation is inhibited compared to in wild-type mice
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microgliosis
(
J:154602
)
|
• in the brain at P20
|
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• oligodendrocytes are deficient in myelination compared to in wild-type mice
• at P14, few myelinated axons are detected in the optic nerve unlike in wild-type mice
• at P21, hardly any myelinated axons are detected in the optic nerve unlike in wild-type mice
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behavior/neurological
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• starting at 2 weeks
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immune system
microgliosis
(
J:154602
)
|
• in the brain at P20
|
hematopoietic system
microgliosis
(
J:154602
)
|
• in the brain at P20
|
