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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ercc3tm1.1Gima
targeted mutation 1.1, Giuseppina Giglia-Mari
MGI:4410296
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ercc3tm1.1Gima/Ercc3tm1.1Gima either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB) MGI:4410311
cx2
 		Ercc3tm1.1Gima/Ercc3tm1.1Gima
Xpctm1Ecf/Xpctm1Ecf 		either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * FVB/N) MGI:4410312


Genotype
MGI:4410311
hm1
Allelic
Composition		 Ercc3tm1.1Gima/Ercc3tm1.1Gima
Genetic
Background		 either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc3tm1.1Gima mutation (0 available); any Ercc3 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:154596 )
N
• mice exhibit normal aging

cellular
cellular phenotype ( J:154596 )
N
• dermal fibroblasts exhibit normal sensitivity to UV-irradiation

reproductive system
reproductive system phenotype ( J:154596 )
N
• mice are fertile

neoplasm
neoplasm ( J:154596 )
N
• mice exhibit normal carcinogenesis




Genotype
MGI:4410312
cx2
Allelic
Composition		 Ercc3tm1.1Gima/Ercc3tm1.1Gima
Xpctm1Ecf/Xpctm1Ecf
Genetic
Background		 either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc3tm1.1Gima mutation (0 available); any Ercc3 mutation (32 available)
Xpctm1Ecf mutation (1 available); any Xpc mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased cellular sensitivity to ultraviolet irradiation ( J:154596 )
• UV-treated dermal fibroblasts exhibit reduced survival compared with similarly treated wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory