All Phenotypes Tg(Ins1-cre/ERT)1Lphi MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ier3ip1^tm1Arvn/Ier3ip1^tm1Arvn Tg(Ins1-cre/ERT)1Lphi/0	involves: 129S4/SvJaeSor * C57BL/6J * CD-1	MGI:7620431
cn2	Gck^tm1Ydor/Gck⁺ Tg(Ins1-cre/ERT)1Lphi/0	involves: C57BL/6 * C57BL/6J * CD-1	MGI:6690684
cn3	Abhd6^{tm1c(EUCOMM)Hmgu}/Abhd6^{tm1c(EUCOMM)Hmgu} Tg(Ins1-cre/ERT)1Lphi/0	involves: C57BL/6N * CD-1	MGI:6276028

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:336782 )

• male mice treated with tamoxifen at 8 weeks of age (to induce IER3IP1 deletion in beta cells in early adulthood) develop a diabetic phenotype

decreased insulin secretion ( J:336782 )

• adult male mice show a reduction of proinsulin and insulin content in pancreatic islets at 2 and 4 weeks after tamoxifen injection

hyperglycemia ( J:336782 )

• adult mice show persistent hyperglycemia at 4 weeks after tamoxifen injection

decreased circulating insulin level ( J:336782 )

• adult mice show decreased serum insulin levels at 4 weeks after tamoxifen injection

impaired glucose tolerance ( J:336782 )

• adult mice show significantly higher blood glucose levels than control littermates at all time points tested in oral glucose tolerance tests starting from 2 weeks after tamoxifen injection

endocrine/exocrine glands

increased pancreatic beta cell apoptosis ( J:336782 )

• pancreatic islets show significantly increased mRNA levels of Trib3 (a mediator of ER stress-induced cell death) at 4 weeks after tamoxifen injection

• in contrast, mRNA levels of the antiapoptotic gene Bcl2 are significantly suppressed

decreased pancreatic beta cell proliferation ( J:336782 )

• pancreatic islets show significantly increased mRNA levels of the cell growth inhibitor p21/Cdkn1a at 4 weeks after tamoxifen injection

abnormal pancreatic beta cell morphology ( J:336782 )

• adult male mice show a more-diffuse cytoplasmic distribution of proinsulin and increased Pro+/Ins-cells at 4 weeks after tamoxifen injection

abnormal pancreatic beta cell differentiation ( J:336782 )

• pancreatic islets of adult male mice show significantly reduced mRNA levels of beta-cell transcription factors both at 2 weeks (Mafa) and at 4 weeks (Mafa, Pdx1, and Nkx6-1) after tamoxifen injection, along with decreases in PDX1 and NKX6-1 protein levels at 4 weeks post-injection

decreased insulin secretion ( J:336782 )

• adult male mice show a reduction of proinsulin and insulin content in pancreatic islets at 2 and 4 weeks after tamoxifen injection

cellular

increased pancreatic beta cell apoptosis ( J:336782 )

• pancreatic islets show significantly increased mRNA levels of Trib3 (a mediator of ER stress-induced cell death) at 4 weeks after tamoxifen injection

• in contrast, mRNA levels of the antiapoptotic gene Bcl2 are significantly suppressed

abnormal pancreatic beta cell differentiation ( J:336782 )

decreased pancreatic beta cell proliferation ( J:336782 )

• pancreatic islets show significantly increased mRNA levels of the cell growth inhibitor p21/Cdkn1a at 4 weeks after tamoxifen injection

Allelic Composition	Gck^tm1Ydor/Gck⁺ Tg(Ins1-cre/ERT)1Lphi/0
Genetic Background	involves: C57BL/6 * C57BL/6J * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gck^tm1Ydor mutation (0 available); any Gck mutation (63 available)
Tg(Ins1-cre/ERT)1Lphi mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hypoglycemia ( J:302600 )

• mice treated with tamoxifen exhibit long-term, persistent hypoglycemia

impaired glucose tolerance ( J:302600 )

• 9-month-old tamoxifen-treated mice, but not 1.5-month-old tamoxifen-treated mice, exhibit abnormal glucose tolerance

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:302600 )

• tamoxifen-treated mice exhibit an increase in beta cell mass at 1.5 months of age, but this increase is no longer seen at 9 months of age

Allelic Composition	Abhd6^{tm1c(EUCOMM)Hmgu}/Abhd6^{tm1c(EUCOMM)Hmgu} Tg(Ins1-cre/ERT)1Lphi/0
Genetic Background	involves: C57BL/6N * CD-1
Cell Lines	HEPD0651_8_C07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abhd6^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Abhd6 mutation (35 available)
Tg(Ins1-cre/ERT)1Lphi mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased insulin secretion ( J:215257 )

• islets from tamoxifen-treated mice show enhanced glucose-stimulated insulin secretion

• however, tamoxifen treated mice show normal body weight, food intake and no changes in beta cell mass

homeostasis/metabolism

increased insulin secretion ( J:215257 )

• islets from tamoxifen-treated mice show enhanced glucose-stimulated insulin secretion

• however, tamoxifen treated mice show normal body weight, food intake and no changes in beta cell mass

increased circulating insulin level ( J:215257 )

• tamoxifen-treated males show elevated insulinemia during oral glucose tolerance test

improved glucose tolerance ( J:215257 )

• tamoxifen-treated males show slightly improved glucose tolerance during oral glucose tolerance test

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