Phenotypes associated with this allele

• Allele Symbol: Del(15Krt7-Krt18)1Tmm
• Allele Name: deletion, Chr 15, Thomas M Magin 1
• Allele ID: MGI:4410584
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(15Krt7-Krt18)1Tmm/Del(15Krt7-Krt18)1Tmm	involves: 129S7/SvEvBrd * C57BL/6	MGI:4411995
cn2	Del(15Krt7-Krt18)1Tmm/+ Igs11^tm1Tmm/Igs11^+ Krt1c^tm1Tmm/Krt1c^+ Tg(ACTB-KRAS*G12V,-luc)#Lche/0	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:5527273
cx3	Del(15Krt7-Krt18)1Tmm/+ Tg(ACTB-KRAS*G12V,-luc)#Lche/0	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:5527266

Genotype
MGI:4411995

hm1

• Allelic Composition: Del(15Krt7-Krt18)1Tmm/Del(15Krt7-Krt18)1Tmm
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Del(15Krt7-Krt18)1Tmm/Del(15Krt7-Krt18)1Tmm embryos exhibit severe growth retardation and apoptosis

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:153804 )

• all die around E9.5

embryo

embryo phenotype ( J:153804 )

N • embryonic and extraembryonic epithelia is intact

increased embryonic tissue cell apoptosis ( J:153804 )

• 10-fold increase in apoptotic cells in embryos, indicating a nutrition defect

embryonic growth retardation ( J:153804 )

• starting around E8.5, fully apparent by E9.5

abnormal embryonic tissue morphology ( J:153804 )

• desmosomes are smaller and partially mislocalized

homeostasis/metabolism

abnormal energy homeostasis ( J:153804 )

• expression analysis indicates a nutrient shortage exists in embryos at E9.5

• addition of exogenous glucose fails to rescue the apparent nutrient shortage

abnormal metabolism ( J:153804 )

• at E9.5 protein biosynthesis is reduced in the embryo and in the yolk sac compared to wild-type controls

cellular

increased embryonic tissue cell apoptosis ( J:153804 )

• 10-fold increase in apoptotic cells in embryos, indicating a nutrition defect

growth/size/body

embryonic growth retardation ( J:153804 )

• starting around E8.5, fully apparent by E9.5

Genotype
MGI:5527273

cn2

• Allelic Composition: Del(15Krt7-Krt18)1Tmm/+; Igs11^tm1Tmm/Igs11⁺; Krt1c^tm1Tmm/Krt1c⁺; Tg(ACTB-KRAS*G12V,-luc)#Lche/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

neoplasm

increased lung tumor incidence ( J:199528 )

• mice treated with an adenovirus expressing Cre recombinase (AdCre) develop lung tumors within 6 weeks of AdCre treatment

• keratin-deficient tumors are typical papillary adenomas and adenocarcinomas, exhibit similar proliferation and apoptosis rates and expression of EMT and neuroendocrine markers as seen in tumors from single Tg(Actb-KRAS*G12V,-luc)#Lche mice

increased lung adenoma incidence ( J:199528 )

• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas

increased lung adenocarcinoma incidence ( J:199528 )

• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas

respiratory system

increased lung tumor incidence ( J:199528 )

• mice treated with an adenovirus expressing Cre recombinase (AdCre) develop lung tumors within 6 weeks of AdCre treatment

• keratin-deficient tumors are typical papillary adenomas and adenocarcinomas, exhibit similar proliferation and apoptosis rates and expression of EMT and neuroendocrine markers as seen in tumors from single Tg(Actb-KRAS*G12V,-luc)#Lche mice

increased lung adenoma incidence ( J:199528 )

• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas

increased lung adenocarcinoma incidence ( J:199528 )

• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas

Genotype
MGI:5527266

cx3

• Allelic Composition: Del(15Krt7-Krt18)1Tmm/+; Tg(ACTB-KRAS*G12V,-luc)#Lche/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

neoplasm

increased lung tumor incidence ( J:199528 )

• mice treated with an adenovirus expressing Cre recombinase (AdCre) develop lung tumors within 6 weeks of AdCre treatment

• tumor load and size of AdCre treated mice is similar to that seen in single Tg(Actb-KRAS*G12V,-luc)#Lche mice

respiratory system

increased lung tumor incidence ( J:199528 )

• mice treated with an adenovirus expressing Cre recombinase (AdCre) develop lung tumors within 6 weeks of AdCre treatment

• tumor load and size of AdCre treated mice is similar to that seen in single Tg(Actb-KRAS*G12V,-luc)#Lche mice