Analysis Tools|
Allele Symbol Allele Name Allele ID |
Stk3tm1Jav targeted mutation 1, Joseph Avruch MGI:4410615 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop multiple spontaneous hepatocellular carcinomas
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• mice develop multiple spontaneous hepatocellular carcinomas
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hepatocellular carcinoma | DOID:684 |
OMIM:114550 |
J:238319 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration
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• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion
• a prominent increase in liver size as early as 3 days after Adeno-Cre administration
• 2-fold larger at 8 days and 4-fold larger by 3 months
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• with a mean latency of 10 weeks after Adeno-Cre injection
• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes
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• with a mean latency of 10 weeks after Adeno-Cre injection
• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes
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• resistance to Fas-Induced Apoptosis in the liver as determined by histological examination, TUNEL staining and western blotting for cleaved caspase-3
|
|
• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration
|
|
• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion
• a prominent increase in liver size as early as 3 days after Adeno-Cre administration
• 2-fold larger at 8 days and 4-fold larger by 3 months
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• develop massively overgrown livers by 3 months of age (4 out of 4)
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• develop hepatocellular carcinomas (HHCs) by 3 months of age (4 out of 4)
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• develop hepatocellular carcinomas (HHCs) by 3 months of age (4 out of 4)
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• develop massively overgrown livers by 3 months of age (4 out of 4)
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration
|
|
• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion
• a prominent increase in liver size as early as 3 days after Adeno-Cre administration
• 2-fold larger at 8 days and 4-fold larger by 3 months
|
|
• with a mean latency of 10 weeks after Adeno-Cre injection
• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes
|
|
• with a mean latency of 10 weeks after Adeno-Cre injection
• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes
|
|
• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration
|
|
• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion
• a prominent increase in liver size as early as 3 days after Adeno-Cre administration
• 2-fold larger at 8 days and 4-fold larger by 3 months
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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